Results 71 to 80 of about 141,166 (348)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Correlation between Total Lymphocyte Count, Hemoglobin, Hematocrit and CD4 Count in HIV/AIDS Patients [PDF]

Acta Medica Iranica, 2009
Lymphocyte CD4+count, a standard laboratory test for staging of HIV infection, is expensive and unavailable in resource-restricted countries. Total lymphocyte count (TLC) and hemoglobin (Hb) are recommended as simple & inexpensive surrogates.
Seyed Mohammad Alavi, Fatemeh Ahmadi, Majid Farhadi   +2 more
doaj   +1 more source

Possible Use of Absolute Lymphocyte Count as Surrogate for CD4+ Cells Count in Monitoring Response to Highly Active Antiretroviral Therapy in Sokoto.

Sokoto Journal of Medical Laboratory Science, 2016
Few laboratories in resource-constrained countries can afford to perform laboratory-monitoring tests required for the management of HIV therapy. The initiation of an antiretroviral therapy is based on CD4+ count less than 350 cells/mm3according to the ...
Onuigwe, F.U., Alimi, R., Balarabe, I., Uko, E., Uchechukwu, N.J., Erhabor, O.
doaj  

Time to and Predictors of CD4+ T-Lymphocytes Recovery in HIV-Infected Children Initiating Highly Active Antiretroviral Therapy in Ghana

AIDS Research and Treatment, 2011
Background. CD4+ T-lymphocyte monitoring is not routinely available in most resource-limited settings. We investigated predictors of time to CD4+ T-lymphocyte recovery in HIV-infected children on highly active antiretroviral (HAART) at Korle-Bu Teaching ...
Lorna Renner, Meghan Prin, Fang-Yong Li, Bamenla Goka, Veronika Northrup, Elijah Paintsil   +5 more
doaj   +1 more source

Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes’ iTNF-α Expression

Biology, 2021
In December 2019, a novel coronavirus, “SARS-CoV-2”, was recognized as the cause of coronavirus disease 2019 (COVID-19). Several studies have explored the changes and the role of inflammatory cells and cytokines in the immunopathogenesis of the disease ...
Gabriele Madonna, Silvia Sale, Mariaelena Capone, Chiara De Falco, Valentina Santocchio, Tiziana Di Matola, Giuseppe Fiorentino, Caterina Pirozzi, Anna D’Antonio, Rocco Sabatino, Lidia Atripaldi, Umberto Atripaldi, Marcello Raffone, Marcello Curvietto, Antonio Maria Grimaldi, Vito Vanella, Lucia Festino, Luigi Scarpato, Marco Palla, Michela Spatarella, Francesco Perna, Pellegrino Cerino, Gerardo Botti, Roberto Parrella, Vincenzo Montesarchio, Paolo Antonio Ascierto, Luigi Atripaldi   +26 more
doaj   +1 more source

Experimental Pulmonary Granuloma Mimicking Sarcoidosis Induced by Propionibacterium acnes in Mice [PDF]

, 2010
Propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. We experimentally produced a murine pulmonary granuloma model using P.
Ichikawa, Hirohisa, Iio, Kouji, Iio, Tomoe Ueno, Kanehiro, Arihiko, Kataoka, Mikio, Miyahara, Nobuaki, Nakata, Yasunari, Okui, Yuhei, Tanimoto, Mitsune, Tanimoto, Yasushi   +9 more
core   +1 more source

CORRELATION OF TOTAL LYMPHOCYTE COUNT WITH CD4 COUNT IN HIV/TB COINFECTED PATIENTS [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
HIV-TB co-infection is a global challenge in the healthcare world. HIV infection causes CD4  to decrease which has a role in TB immunity. CD4 as a marker for HIV progression have expensive cost and not available in all healthcare facilities, so WHO recommended TLC as a substitute for CD4.
Herniaty Rampo, Uleng Bahrun, Mansyur Arif   +2 more
openaire   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Dedrick, R., Dummer, W., Joshi, A., Jullien, D., Langley, RGB, Natta, P., Prinz, Jörg Christoph   +7 more
core   +1 more source