Results 111 to 120 of about 14,389,011 (296)

Suppression of allergic airway inflammation by helminth-induced regulatory T cells [PDF]

, 2005
Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections ...
Lamb, Jonathan, Mark S. Wilson, Adam Balic, Constance A.M. Finney, Taylor, Matthew D, Finney, Constance A, Matthew D. Taylor, Rick M. Maizels, Maizels, Rick, Jonathan R. Lamb, Wilson, Mark A, Balic, Adam   +11 more
core   +1 more source

The potential of CD4 T‐cell memory

Immunology, 2010
SummaryWhile many aspects of memory T‐cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T‐cell responses is key to the development of improved vaccines against many prominent pathogens ...
K Kai, McKinstry, Tara M, Strutt, Susan L, Swain   +2 more
openaire   +3 more sources

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S   +42 more
core   +2 more sources

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2–IL-6 cascade

Journal for ImmunoTherapy of Cancer, 2019
Background CD4+ T cells are critical effectors of anti-tumor immunity, but how tumor cells influence CD4+ T cell effector function is not fully understood.
Yong-Qiang Chen, Peng-Cheng Li, Ning Pan, Rong Gao, Zhi-Fa Wen, Tian-Yu Zhang, Fang Huang, Fang-Yuan Wu, Xi-Long Ou, Jin-Ping Zhang, Xue-Jun Zhu, Hong-Ming Hu, Kang Chen, Yun-Lang Cai, Li-Xin Wang   +14 more
doaj   +1 more source

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, EarlyView.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija, Benjamin M Kagina, Willem A Hanekom, Nicole Lenz (671838), Hoff, Søren T., Fielding, Katherine L., Ingrid Kromann (370517), Khadija Said, Hannah Jeffery, Gardiner, Nicolene, Trevor Beattie (671836), Willem A. Hanekom (125097), Daubenberger, Claudia, Klaus Reither, Peter Andersen, Trevor Beattie, Fielding, Katherine L, Scriba, Thomas J, Hoff, Søren T, Søren T. Hoff (246744), Ingrid Kromann, Pohl, Christian, Klaus Reither (259897), Landay, Alan, Katsoulis, Lynn, Lynn Katsoulis, Scriba, Thomas J., Katherine L Fielding, Bang, Peter, Christian Pohl, Peter Bang (671842), Jeffery, Hannah, Peter Bang, Hannah Jeffery (671839), Nicolene Gardiner (671837), Elisabeth J. Hughes (671841), Claudia Daubenberger, Elirehema Mfinanga (476407), Elisabeth J Hughes, Søren T Hoff, Hughes, Elisabeth J., Gavin J. Churchyard (143332), Elirehema Mfinanga, Kagina, Benjamin M, Nicole Lenz, Benjamin M. Kagina (671840), Thomas J Scriba, Khadija Said (476408), Churchyard, Gavin J, Hanekom, Willem A., Mfinanga, Elirehema, Beattie, Trevor, Christian Pohl (476404), Kagina, Benjamin M., Andersen, Peter, Hanekom, Willem A, Reither, Klaus, Nicolene Gardiner, Thomas J. Scriba (76847), Claudia Daubenberger (212658), Lynn Katsoulis (671835), Kromann, Ingrid, Gavin J Churchyard, Hughes, Elisabeth J, Peter Andersen (88335), Churchyard, Gavin J., Lenz, Nicole, Katherine L. Fielding (143336)   +67 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Characterisation of Mycobacterium tuberculosis specific T cell immunity with HLA class II tetramers [PDF]

, 2014
Includes bibliographical references.Tuberculosis (TB) remains a global health burden, with an estimated 1.3 million people dying from the disease in 2012. Protective immunity against TB is thought to depend on specific T cells.
Dintwe, One Bridget
core   +1 more source