Results 101 to 110 of about 15,293,201 (302)

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Characteristics of PD‐1+CD4+ T cells in peripheral blood and synovium of rheumatoid arthritis patients

Clinical & Translational Immunology
Objectives PD‐1 plays a crucial role in the immune dysregulation of rheumatoid arthritis (RA), but the specific characteristics of PD‐1+CD4+ T cells remain unclear and require further investigation.
Yan‐juan Chen, Yong Chen, Ping Chen, Yi‐qun Jia, Hua Wang, Xiao‐ping Hong   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. [PDF]

, 2007
Investigation of the role of regulatory T cells (Treg) in model systems is facilitated by their depletion using anti-CD25 Abs, but there has been considerable debate about the effectiveness of this strategy.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., De Souza, J. Brian, de Souza, J Brian, Suffia, Isabelle, Riley, Eleanor M., Belkaid, Yasmine   +9 more
core   +1 more source

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control

Inflammation and Regeneration
Background Induced pluripotent stem cell (iPSC)–derived T cells offer a renewable source for off-the-shelf immunotherapy. With the advent of the artificial thymic organoid (ATO) method, the in vitro differentiation of CD4+ T cells from iPSCs has also ...
Qingyi Guo, Chaoqi Zhang, Bo Wang, Shoichi Iriguchi, Akihiro Ishikawa, Atsutaka Minagawa, Tomoko Ishii, Yohei Kawai, Shin Kaneko   +8 more
doaj   +1 more source

Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation

Frontiers in Immunology, 2019
Idiopathic T-CD4 lymphocytopenia (ICL) is a rare and heterogeneous syndrome characterized by opportunistic infections due to reduced CD4 T-lymphocytes (<300 cells/μl or <20% T-cells) in the absence of HIV infection and other primary causes of ...
Rosa Anita Fernandes, Martin Perez-Andres, Martin Perez-Andres, Martin Perez-Andres, Elena Blanco, Elena Blanco, Elena Blanco, Maria Jara-Acevedo, Maria Jara-Acevedo, Maria Jara-Acevedo, Ignacio Criado, Ignacio Criado, Ignacio Criado, Julia Almeida, Julia Almeida, Julia Almeida, Vitor Botafogo, Vitor Botafogo, Vitor Botafogo, Ines Coutinho, Artur Paiva, Artur Paiva, Artur Paiva, Jacques J. M. van Dongen, Alberto Orfao, Alberto Orfao, Alberto Orfao, Emilia Faria   +27 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Maturation and mip-1β production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults : impact by HIV and Mycobacterium tuberculosis co-infections [PDF]

, 2015
It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4+ and CD8+
Elmar Saathoff, Petra Clowes, Ntinginya, Nyanda E., Andrea Rachow, Philipp Metzger (739291), Clowes, Petra, Mkunde Chachage (543774), Elmar Saathoff (4991), Haraka, Frederick, Metzger, Philipp, Geldmacher, Christof, Klaus Reither, Michael Hoelscher (151418), Asli Bauer (543776), Saathoff, Elmar, Daubenberger, Claudia A., Klaus Reither (259897), Asli Bauer, Damien Portevin, Nyanda E. Ntinginya, Claudia A. Daubenberger, Nyanda E Ntinginya, Moukambi, Félicien, Claudia A Daubenberger, Mpina, Maxmillian, Christof Geldmacher (317649), Bauer, Asli, Damien Portevin (228474), Hoelscher, Michael, Philipp Metzger, Rachow, Andrea, Michael Hoelscher, Chachage, Mkunde, Petra Clowes (175598), Frederick Haraka, Frederick Haraka (727977), Mkunde Chachage, Maxmillian Mpina (212648), Andrea Rachow (313495), Reither, Klaus, Félicien Moukambi (739290), Damien Portevin, Christof Geldmacher, Claudia A. Daubenberger (739293), Félicien Moukambi, Maxmillian Mpina, Portevin, Damien, Nyanda E. Ntinginya (739292), Geldmacher Christof, Bauer A, Reither K, Hoelscher M, Hoelscher Michael, Daubenberger Claudia A., Haraka F, Bauer Asli, Moukambi F, Saathoff Elmar, Haraka Frederick, Chachage Mkunde, Clowes P, Clowes Petra, Portevin Damien, Rachow A, Metzger Philipp, Mpina Maxmillian, Metzger P, Moukambi Félicien, Daubenberger CA, Ntinginya NE, Geldmacher C, Portevin D, Ntinginya Nyanda E., Saathoff E, Rachow Andrea, Reither Klaus, Chachage M, Mpina M   +77 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment [PDF]

, 2012
PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core   +2 more sources