Results 81 to 90 of about 14,389,011 (296)
The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. [PDF]
, 2013 Includes abstract.Includes bibliographical references.Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis.
Smith, Liezel C
core +1 more source
Frontiers in Immunology, 2016 We have shown that Cholera Toxin (CT) and other cyclic AMP (cAMP) elevating agents induce up-regulation of the inhibitory molecule CTLA-4 in human resting CD4+ T lymphocytes, which following the treatment acquired suppressive functions. In this study, we
Antonella Riccomi +4 more
doaj +1 more source
Dynamic transcription of long non-coding RNA genes during CD4+ T cell development and activation. [PDF]
PLoS ONE, 2014 BACKGROUND: Recent evidence shows that long non-coding RNA (LncRNA) play important regulatory roles in many biology process, including cell development, activation and oncogenesis.
Fei Xia +7 more
doaj +1 more source
CD4 T cells in tumor immunity [PDF]
Springer Seminars in Immunopathology, 2005 T cell immunity is the key to protective immune responses against tumors. Traditionally, this function has been ascribed to CD8 T lymphocytes with cytotoxic activity, which are restricted by MHC class I molecules. In recent years the realization that CD4 T cells can also play a relevant role in protective anti-tumor responses has received growing ...
Gerloni, Mara, Zanetti, Maurizio
openaire +3 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Analysis of the transcriptional program of developing induced regulatory T cells. [PDF]
, 2011 CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we performed
Lipsky, Peter E. +8 more
core +2 more sources
Clinical and Developmental Immunology, 2013 Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R).
Marcin Moniuszko +13 more
doaj +1 more source
CD4+ T cells: The great escape
Nature Medicine, 2001 Mutation is one way in which RNA viruses evade the destructive actions of CD8+ cytotoxic lymphocytes. New research shows that they employ the same method to escape attack by CD4+ T cells. (pages 795–800)
Phillips, R, Harcourt, G, Price, D
openaire +2 more sources
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source