Results 261 to 270 of about 15,293,201 (302)
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Current Opinion in Rheumatology, 2007
Many autoimmune rheumatic autoimmune disorders predominantly affect women. Sex hormones, in particular estrogen, can influence CD4 T-helper development and function. We highlight recent studies that begin to provide insights into the mechanisms by which estrogen modulates CD4 T-cell development and function, and thus potentially contribute to disease ...
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Many autoimmune rheumatic autoimmune disorders predominantly affect women. Sex hormones, in particular estrogen, can influence CD4 T-helper development and function. We highlight recent studies that begin to provide insights into the mechanisms by which estrogen modulates CD4 T-cell development and function, and thus potentially contribute to disease ...
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NeoReviews, 2013
The immune system has evolved to fend off challenges from a wide array of pathogens while maintaining tolerance to self-antigens and benign environmental antigens. CD4 helper T cells are critical in regulating these processes with different subsets of CD4 T cells responsible for regulating different facets of the immune system.
Emily G. Blosser, David A. Randolph
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The immune system has evolved to fend off challenges from a wide array of pathogens while maintaining tolerance to self-antigens and benign environmental antigens. CD4 helper T cells are critical in regulating these processes with different subsets of CD4 T cells responsible for regulating different facets of the immune system.
Emily G. Blosser, David A. Randolph
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Current Opinion in Immunology, 2008
The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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Idiopathic CD4+ T-cell lymphocytopenia
The Indian Journal of Pediatrics, 2009Idiopathic CD4+ T lymphocytopenia (ICL) is an unusual immune defect in which there is an unexplained deficit of CD4+ T cells, leading to serious opportunistic infections. In view of the rarity of this clinical entity, we report two cases of ICL who presented with low CD4+ count or percentage and various opportunistic infections like candida ...
Aparna, Mukherjee +2 more
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CD4+ T-Cell Differentiation In Vitro
2020CD4+ T helper cells play crucial roles in adaptive immune response against pathogens, as well as in host immune homeostasis. Upon TCR activation, naïve CD4+ T cells differentiate into one of several lineages of Th cells, with hallmark transcription factors, cytokine production, and functions in vivo, according to the particular cytokine milieu.
Wenyong, Yang, Xueying, Chen, Hongbo, Hu
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2003
The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
A A, Delvig, J H, Robinson
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The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
A A, Delvig, J H, Robinson
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CD4+ T Cell Differentiation and Activation
2018The activation and differentiation of CD4+ T cells play a critical role in establishing and subsequently controlling protective adaptive immune responses. Flow cytometry is a powerful technique with which to assess the potential of xenobiotics to influence CD4+ T cell activation and differentiation.
Jim, Reed, Scott A, Wetzel
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Current Opinion in Immunology, 2011
Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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CD4+ T-cell subsets in autoimmunity
Current Opinion in Immunology, 1997The discovery that functionally heterogeneous CD4+ T-cell subsets secrete different cytokines offers an explanation for the ability of certain T cells to mediate a predominant cell-mediated immune response versus a humoral response often accompanied by allergic manifestations. Th1 cells, important for cell-mediated immunity by their production of IL-2,
A, O'Garra, L, Steinman, K, Gijbels
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Heterogeneity of CD4+ and CD8+ T cells
Current Opinion in Immunology, 2003There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized.
David L, Woodland, Richard W, Dutton
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