Results 51 to 60 of about 68,812 (293)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation

BMC Cancer, 2022
Background Several studies showed that lack of CD56 expression was a poor prognostic factor for patients with newly diagnosed multiple myeloma (NDMM). However, other studies were not able to confirm the prognostic value of CD56 in NDMM.
Chuanying Geng, Huixing Zhou, Huijuan Wang, Yanchen Li, Yun Leng, Zhiyao Zhang, Yuan Jian, Guangzhong Yang, Wenming Chen   +8 more
doaj   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

CD56 and RUNX1 isoforms in AML prognosis and their therapeutic potential

Hematology/Oncology and Stem Cell Therapy, 2016
Neural cell adhesion molecule (NCAM/CD56) expression in acute myeloid leukemia (AML) has been associated with extramedullary leukemia, multidrug resistance, shorter remission and survival. Recently, Bloomfield et al. published a succinct review of issues
Syed Z.A. Zaidi, Ibraheem H. Motabi, Ali Al-Shanqeeti   +2 more
doaj   +1 more source

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

Frontiers in Immunology, 2022
ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype.
Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li, Yingshi Piao, Yingshi Piao, Xindi Liu, Liqiang Wei, Wei Sang, Luo Zhang, Luo Zhang, Liang Wang, Liang Wang   +12 more
doaj   +1 more source

CD56+dim and CD56+bright cell activation and apoptosis in hepatitis C virus infection

Clinical and Experimental Immunology, 2004
SUMMARYCD3–CD56+dim natural killer (NK) cells, which are cytotoxic against virally infected cells, may be important in hepatitis C virus (HCV)-infected patients who are successfully treated with pegylated interferon (PEG-IFN)-α. We used flow cytometry to enumerate activated (CD69+) and apoptotic (annexin-V+) dim (CD3–CD56+dim) and bright (CD3–CD56 ...
A W, Lin, S A, Gonzalez, S, Cunningham-Rundles, G, Dorante, S, Marshall, A, Tignor, C, Ha, I M, Jacobson, A H, Talal   +8 more
openaire   +3 more sources

Total CD3+, Total CD56+ and CD3+CD56− T cell populations in patients maintaining or withdrawing therapy.

, 2013
Graphs illustrate total CD3+, Total CD56+ and CD3+CD56− T cell populations (expressed as a percentage of the lymphogate) in patients maintaining or withdrawing therapy at baseline (▴) and three months ...
Elizabeth J. Ryan (339092), Ursula Fearon (8519), Oliver FitzGerald (26005), Douglas J. Veale (339506), Barry Bresnihan (26006), Ceara E. Walsh (339504), Cliona O’Farrelly (339505), Lucy Golden-Mason (242863)   +7 more
core   +1 more source

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

The unexpected effect of cyclosporin A on CD56+CD16− and CD56+CD16+ natural killer cell subpopulations

Blood, 2007
AbstractCyclosporin A (CSA) is commonly used to prevent graft-versus-host disease. The influence of CSA on T-cell function has been extensively investigated; however, the effect of CSA on natural killer (NK) cells is less understood. NK cells were cultured with IL-2 and IL-15 with and without CSA for 1 week. Compared with controls, CSA-treated cultures
Hongbo, Wang, Bartosz, Grzywacz, David, Sukovich, Valarie, McCullar, Qing, Cao, Alisa B, Lee, Bruce R, Blazar, David N, Cornfield, Jeffrey S, Miller, Michael R, Verneris   +9 more
openaire   +3 more sources

Giant omental lipoblastoma and CD56 expression

, 2014
We report a case of giant omental lipoblastoma in a 13-month-old boy, which was treated successfully by total excision. Tumor cells were positive for S100,CD34 and CD56. This is the fi rst report of lipoblastoma expressing CD56, a fact that could be used
Miyano, G, Arakawa, A, Goto, S, Hayashi, T, Yamataka, A, Lane, GJ, Okazaki, T   +6 more
core   +1 more source