Results 71 to 80 of about 68,812 (293)

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Clinical significance of aberrant expression of CD56 on newly diagnosed adult acute myeloid leukemia blast cells

Iraqi Journal of Hematology
BACKGROUND: Acute myeloid leukemia (AML) is a clonal malignancy affecting hemopoietic immature cells, characterized by uncontrolled proliferation and impaired differentiation of these cells, causing their accumulation in the marrow and ultimately marrow ...
Najwan Salih Nima, Sura Kanaan Mejeed
doaj   +1 more source

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia

BMC Cancer, 2022
Background Many cytogenetic changes and gene mutations are associated with acute myeloid leukemia (AML) survival outcomes. CD56 is related to poor prognosis when expressed in adult AML patients.
Tianqi Liang, Zhiyong Peng, Chunfu Li, Junbin Huang, Huabin Wang, Chaoke Bu, Jian Li, Yongzhi Zheng, Xiaoqin Feng, Huiping Li, Chun Chen   +10 more
doaj   +1 more source

CD56 Expression in Feline Lymphoid Cells

Journal of Veterinary Medical Science, 2003
The neural-cell adhesion molecule (N-CAM) consists of three major types of polypeptides (180, 140, and 120 kDa) whose predominant differences exist within the transmembrane and cytoplasmic domains. In this study, we generated a monoclonal antibody, termed SZK1, reactive to feline CD56 (fCD56) molecules (140 kDa form of N-CAM) expressed by the ...
SHIMOJIMA, Masayuki, NISHIMURA, Yorihiro, MIYAZAWA, Takayuki, KATO, Kentaro, TOHYA, Yukinobu, AKASHI, Hiroomi   +5 more
openaire   +3 more sources

Transcription factors and MAPK signaling in CD56 subset.

, 2014
EOMES and T-bet control cytotoxic function of effector T cells. (A) Majority of CD56+ CD8 T cells expressed T-bet and/or EOMES and were double positive for these transcription factors, whereas a significant proportion of CD56- CD8 T cells were double ...
C. David Pauza (358594), Bhawna Poonia (358592)   +1 more
core   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

Control of CD56 expression and tumor cell cytotoxicity in human Vγ2Vδ2 T cells

BMC Immunology, 2009
Background In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) correlates with cytotoxic effector activity. For cells bearing the Vγ2Vδ2 T cell receptor, isoprenoid pyrophosphate stimulation leads to uniform activation and ...
Focaccetti Chiara, Armstrong Cheryl, Li Haishan, Urban Elizabeth M, Cairo Cristiana, Pauza C David   +5 more
doaj   +1 more source

Circulating tumor plasma cells quantification in newly diagnosed transplant ineligible real world multiple myeloma patients: Comparison of single‐platform flow cytometry versus next generation flow

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating tumor plasma cells (CTCs) at diagnosis are independent prognostic markers in newly diagnosed multiple myeloma (NDMM). Flow cytometry (FC) enables sensitive and cost‐effective CTC quantification, but prognostic cut‐offs vary across studies.
Elona Saraci, Alessandra Larocca, Roberto Ria, Silvia Mangiacavalli, Giulia Benevolo, Nicola Giuliani, Renato Zambello, Angelo Belotti, Ilaria Rizzello, Antonietta Pia Falcone, Iolanda Donatella Vincelli, Mariagrazia Michieli, Sonia Ronconi, Patrizia Tosi, Maria letizia Mosca Siez, Alessandro Allegra, Maide Maria Cavalli, Matilde Scaldaferri, Ilaria Fedele, Marco Burdisso, Tania Villanova, Cristina Velluti, Marcello Capriata, Donato Mannina, Anna Maria Cafro, Elisabetta Antonioli, Sonia Morè, Mario Boccadoro, Benedetto Bruno, Sara Bringhen, Mattia D'Agostino   +30 more
wiley   +1 more source

Beyond Uterine Natural Killer Cell Numbers in Unexplained Recurrent Pregnancy Loss: Combined Analysis of CD45, CD56, CD16, CD57, and CD138

Diagnostics, 2020
Changes in the number and cytotoxic potential of uterine Natural Killer (uNK) cells have been associated with reduced fertility. To provide a better characterization of immunophenotypes in the endometrium of women with uRPL (unexplained recurrent ...
Maia Chiokadze, Christin Bär, Jana Pastuschek, Boris V. Dons’koi, Kseniia G. Khazhylenko, Ekkehard Schleußner, Udo R. Markert, Rodolfo R. Favaro   +7 more
doaj   +1 more source