Results 91 to 100 of about 447,008 (222)
Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment
The FEBS Journal, EarlyView.Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro +13 more
wiley +1 more source
Merkel cell carcinoma: an updated guide for pathologists
Histopathology, EarlyView.Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley +1 more source
Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix
Histopathology, EarlyView.Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake +12 more
wiley +1 more source
International Journal of Dermatology, EarlyView.Subcutaneous panniculitis‐like T‐cell lymphoma. Survival outcomes according to the presence of hemophagocytic lymphohistiocytosis (HLH) and T category. Relapse‐free survival was inferior in patients presenting with generalized (T3) skin lesions. Overall survival was poor in patients with HLH. Relapse‐free survival was also reduced in patients with HLH.
Myoung Eun Choi +6 more
wiley +1 more source
Bioactive MaterialsObjective: This study aimed to develop a novel, targeted therapy for lumbar facet joint osteoarthritis (LFJ OA) by identifying a potent bone mesenchymal stem cell (BMSC) subpopulation for cartilage regeneration, engineering its exosomes (Exos) for ...
Yong Xie +11 more
doaj +1 more source
ICSH Guidance on Bone Marrow Examination and Reporting
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber +6 more
wiley +1 more source
Enterobacterial common antigen in mutant strains of Salmonella. [PDF]
, 1978 A good correlation was found to exist between the serologically determined presence of enterobacterial common antigen (ECA) and the amount of the rare sugar constituent D-mannosaminuronic acid.
Mayer, H. +2 more
core +1 more source
Reproductive Biology and Endocrinology, 2009 Background Changes in the balance of decidual leucocyte populations may lead to an unfavourable uterine microenvironment which may be associated with the development of preeclampsia (PE).
Rieger Lorenz +7 more
doaj
Immunology, EarlyView.This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann +7 more
wiley +1 more source
The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]
, 2008 CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Christoph Uherek +20 more
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