Results 121 to 130 of about 447,008 (222)

Dual‐Targeted M1 Macrophage Extracellular Vesicles Reprogram the Tumor Microenvironment and Enhance Natural Killer Cell Immunotherapy in Breast Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Dual‐targeted extracellular vesicles (EV) engineered from M1 macrophages (M1EV_HA/cRGD) bridge NK cells to breast cancer cells while activating pro‐inflammatory programs within the tumor microenvironment. Hyaluronic acid (HA) enables CD44‐mediated NK targeting, and cRGD binds tumor integrins for targeted dual engagement.
Su Jin Kang, Gichan Baek, Suwun Ju, Gunhee Kim, Seongjin Gwak, Won Jong Rhee   +5 more
wiley   +1 more source

Direct involvement of CD56 in cytokine-induced killer–mediated lysis of CD56+ hematopoietic target cells

, 2014
Cytokine-induced killer (CIK) cells are in-vitro-expanded T lymphocytes that represent a heterogeneous population. A large majority of CIK cells are CD3(+)CD56(+), and this population has been shown to confer a cytotoxic effect against tumor targets. The
Cristina Capitanio, Pesenti, Enrico, Capitanio, Cristina, Introna, Martino, Alessandro Rambaldi, Valgardsdottir, Rut, Texido, Gemma, Rambaldi, Alessandro, Claudia Cantoni, Enrico Pesenti, Pende, Daniela, Rut Valgardsdottir, Daniela Pende, Martino Introna, Golay, Josée, Gemma Texido, Josée Golay, CANTONI, CLAUDIA   +17 more
core   +1 more source

Expression of CD56/N-CAM antigen and some other adhesion molecules in various human endocrine glands.

Folia histochemica et cytobiologica, 1998
CD56/N-CAM antigen, 140 kDa isoform of neural cell adhesion molecule (N-CAM) has been previously traced by some of us in follicular epithelium of human thyroid by immunohistochemistry. The reaction product was cell membrane bound, being stronger in hyperactive thyroid as compared to colloid goiter.
J, Zeromski, M, Lawniczak, K, Galbas, R, Jenek, P, Golusiński   +4 more
openaire   +1 more source

Detection CD56 antigenic expression of the patient with morfology report LGL in the peripheral blood.

, 2013
Author: Bc. Irena Procházková Job title: Detekce exprese antigenu CD56 u pacientů s morfologickým nálezem LGL v periferní krvi Diploma work Charles Univerzity in Prague, Faculty of Pharmacy in Hradec Králové, Biological and medical department Field of ...
Procházková, Irena
core  

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

Signal Transduction and Targeted Therapy
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease
Lele Sun, Pengcheng Huai, Zhenzhen Wang, Qing Zhao, Yingjie Lin, Tingting Liu, Xiaotong Xue, Suiting Ao, Jiabao You, Yonghu Sun, Zihao Mi, Joshua Gardner, Paul J. Thomson, Dean J. Naisbitt, Xiaoli Meng, Jianjun Liu, Hong Liu, Furen Zhang   +17 more
doaj   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Efficacy and Safety of Co‐Ablation Combined With Aintilimab for Metastatic Melanoma to the Liver (CryoCheck‐001): A Phase II Trial

MedComm, Volume 7, Issue 10, October 2026.
Liver metastasis is a key driver of immune tolerance in patients with melanoma receiving immune checkpoint inhibitor therapy. This single‐arm phase II trial prospectively investigated the efficacy and safety of co‐ablation combined with sintilimab for liver metastatic melanoma.
Lujun Shen, Letao Lin, Shuanggang Chen, Chen Li, Ruizhi Tang, Lin Xie, Yujia Wang, Yunpeng Li, Hongliang Zou, Dandan Li, Xiaoshi Zhang, Weijun Fan   +11 more
wiley   +1 more source

CAR NK cell production from human cord blood NK progenitor cells is enhanced by stimulation of the IL-15 receptor

Cancer Immunology, Immunotherapy
Cord blood (CB)-derived chimeric antigen receptor (CAR) natural killer (NK) cells have demonstrated significant antitumor efficacy. We recently reported that CB-derived CAR NK cells predominantly originate from CD7+CD56−CD34−HLA-DR−Lin− NK cell ...
Yosuke Kogue, Shunya Ikeda, Yuto Maehara, Ryuhei Kawamoto, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Emiko Mizuta, Yo Mizutani, Yuta Yamaguchi, Daisuke Okuzaki, Naoki Hosen   +13 more
doaj   +1 more source