Results 71 to 80 of about 13,567 (213)
Advanced Science, Volume 13, Issue 25, 4 May 2026.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable +6 more
wiley +1 more source
Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka +4 more
wiley +1 more source
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017 The combination of nanotechnology and medicine will be the next generation of vehicles for targeted drug delivery. Carboxymethyl chitosan loaded with the anticancer drug C-phycocyanin and the CD59-specific ligand peptide for cancer cell targeting were ...
Peng Yang +3 more
semanticscholar +1 more source
Indian Journal of Pathology and Microbiology, 2010 Context: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 ...
Tembhare Prashant +3 more
doaj
VirusesMicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNA-seq profiling of miRNAs and mRNAs expressed in CD4+ T lymphocytes upon HIV-1 infection.
Nicolas Bellini +5 more
doaj +1 more source
Complement susceptibility in glutamine deprived breast cancer cells
Cell Division, 2007 Background Membrane complement regulatory proteins (mCRPs) inhibit complement-mediated killing of human cells by human complement, a property that confers protection from complement to malignant breast cancer cells and that thwarts some immunotherapies ...
Boackle Robert J +2 more
doaj +1 more source
Uncontrolled inflammation of the nervous system: Inherited CD59 deficiency.
Neurology Clinical Practice, 2018 CD59 regulates the complement activation cascade at the final step by inhibiting formation of membrane attack complex. The lack of CD59 allows uncontrolled complement amplification following spontaneous, viral, or postviral induced complement activation.
D. Yuksel +6 more
semanticscholar +1 more source
Clinical and Developmental Immunology, 2012 CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated.
Ana Paula Alegretti +6 more
doaj +1 more source
A role for GPI-CD59 in promoting T-cell signal transduction via LAT
Oncology Letters, 2018 Cluster of differentiation 59 (CD59) is a glycosylphosphatidylinositol-anchored protein. Cross-linking of CD59 with specific monoclonal antibodies can cause a series of intracellular signal transduction events.
Lina Wang +4 more
semanticscholar +1 more source