Results 61 to 70 of about 9,613 (181)

Flow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55

Indian Journal of Pathology and Microbiology, 2010
Context: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 ...
Tembhare Prashant, Ramani Manisha, Syed Keerti, Gupta Amar   +3 more
doaj  

Downregulation of miRNA-26a by HIV-1 Enhances CD59 Expression and Packaging, Impacting Virus Susceptibility to Antibody-Dependent Complement-Mediated Lysis

Viruses
MicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNA-seq profiling of miRNAs and mRNAs expressed in CD4+ T lymphocytes upon HIV-1 infection.
Nicolas Bellini, Chengyu Ye, Oluwaseun Ajibola, Thomas T. Murooka, Robert Lodge, Éric A. Cohen   +5 more
doaj   +1 more source

Complement susceptibility in glutamine deprived breast cancer cells

Cell Division, 2007
Background Membrane complement regulatory proteins (mCRPs) inhibit complement-mediated killing of human cells by human complement, a property that confers protection from complement to malignant breast cancer cells and that thwarts some immunotherapies ...
Boackle Robert J, Zanin Mary KB, Ellison Bradley S   +2 more
doaj   +1 more source

Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients

Clinical and Developmental Immunology, 2012
CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated.
Ana Paula Alegretti, Laiana Schneider, Amanda Kirchner Piccoli, Odirlei Andre Monticielo, Priscila Schmidt Lora, João Carlos Tavares Brenol, Ricardo Machado Xavier   +6 more
doaj   +1 more source

CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex

Brain Sciences
Cerebral amyloid angiopathy is characterized by a weakening of the small- and medium-sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to ...
Carson D. Whinnery, Ying Nie, Danilo S. Boskovic, Salvador Soriano, Wolff M. Kirsch   +4 more
doaj   +1 more source

Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best
Lacy Cardoso de Brito Junior, Maria do Socorro de Oliveira Cardoso, Euzamar Gaby Rocha, Herika Anijar, Mariana Cunha, João Carlos Pina Saraiva   +5 more
doaj   +1 more source

Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia

Platelets, 2017
In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger, Beate Eichelberger, Anja Ulz, Simon Panzer   +3 more
doaj   +1 more source

The potential role of cell surface complement regulators and circulating CD4+ CD25+ T-cells in the development of autoimmune myasthenia gravis

Electronic Physician, 2016
Introduction: CD4+CD25+ regulatory T-lymphocytes (T-regs) and regulators of complement activity (RCA) involving CD55 and CD59 play an important role in the prevention of autoimmune diseases.
Mohamed Nasreldin Thabit Hamdoon, Mona Fattouh, Asmaa Nasr El-din, Hassan M. Elnady   +3 more
doaj   +1 more source

Molecular characterization of CD59 and gmfb genes and their differential expression in Piaractus orinoquensis exposed to different conditions of brain injury

Open Veterinary Journal
Background: Neuroinflammation can be triggered by several causes, including traumatic brain injury (TBI) and exposure to toxicants such as chlorpyrifos (CPF), leading to chronic disabilities and substantial healthcare costs.
Rafael Enrique Castro-Vargas, María Paula Herrera-Sanchez, Iang Rondón-Barragan   +2 more
doaj   +1 more source

Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia

Malaria Journal, 2011
Background Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Gwamaka Moses, Fried Michal, Domingo Gonzalo, Duffy Patrick E   +3 more
doaj   +1 more source