Results 61 to 70 of about 7,063 (170)

Association of integrin expression in tumor tissue with hematogenic metastasis of breast cancer

Сибирский онкологический журнал
Background. Distant hematogenous metastasis is the leading cause of tumor-related death from breast cancer. To prevent metastasis, prognostic markers for predicting the risk and location of hematogenous metastases are required.
M. V. Zavyalova, G. A. Kuznetsov, E. S. Grigoryeva, L. A. Tashireva, D. S. Pismenny, V. M. Perelmuter   +5 more
doaj   +1 more source

Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation

Frontiers in Pharmacology, 2019
Objective: The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could ameliorate pressure overload-induced heart hypertrophy and its mechanisms.Methods: C57BL/6 mice were subjected to either sham or transverse aortic ...
Congping Su, Qing Wang, Huimin Zhang, Wenchao Jiao, Hui Luo, Lin Li, Xiangyang Chen, Bin Liu, Xue Yu, Sen Li, Wei Wang, Shuzhen Guo   +11 more
doaj   +1 more source

Correlation of Platelet Receptor Expression in Glanzmann Thrombasthenia with Clinical Presentation and Haematological Parameters

Pakistan Armed Forces Medical Journal
Objective: To correlate platelet receptor expression with clinico-haematological parameters in patients of Glanzmann Thrombasthenia. Study Design: Cross-sectional study.
Ahmad Cheema, Manzar Bozdar, Hamid Saeed Malik, Muhammad Hussain, Rafia Mahmood, Aysha Khan, Ayesha Khurshid, Syeda Samia Shafaat   +7 more
doaj   +1 more source

Flow cytometry immunophenotyping of healthy platelets and hospitalized patients with suspected platelet dysfunction: Challenges for establishing a cutoff value

Hematology, Transfusion and Cell Therapy
Introduction and Objective: Flow Cytometry (FC) is one of the techniques, which allows the identification and characterization of platelets. The detection of absent or reduced expression of the glycoproteins is the main objective of this technique ...
Daiane Keller Cecconello, Fabiane Spagnol, Ana Paula Alegretti, Diogo André Pilger, Mariela Granero Farias   +4 more
doaj   +1 more source

Circulating progenitor cells and their interaction with platelets in patients with an acute coronary syndrome

Platelets, 2019
CD34+ cells expressing KDR (CD34+/KDR+) represent a small proportion of circulating progenitor cells that have the capacity to interact with platelets and to differentiate into mature endothelial cells, thus contributing to vascular homeostasis and ...
Prokopia T. Tatsidou, Vasileios G. Chantzichristos, Maria E. Tsoumani, Sofia Sidiropoulou, Ioannis V. Ntalas, John A. Goudevenos, Konstantinos Stellos, Alexandros D. Tselepis   +7 more
doaj   +1 more source

Carbon-Encapsulated Iron Nanoparticles Seeking Integrins in Murine Glioma

International Journal of Nanomedicine
Agnieszka Stawarska,1,* Magdalena Bamburowicz-Klimkowska,1,* Michał Bystrzejewski,2 Artur Kasprzak,3 Ireneusz P Grudzinski1 1Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland ...
Stawarska A, Bamburowicz-Klimkowska M, Bystrzejewski M, Kasprzak A, Grudzinski IP   +4 more
doaj  

Advances and challenges in platelet counting: evolving from traditional microscopy to modern flow cytometry

Journal of Laboratory Medicine
Platelet counting is a fundamental clinical test for diagnosing haemorrhagic diseases, coagulation abnormalities, and certain autoimmune disorders, and it also serves as a critical basis for decisions regarding platelet transfusion.
Chen Yong, Hu Yonggang, Hu Hai
doaj   +1 more source

The CD41/CD61 (GPIIb/IIIa) complex contributes to human neutrophil adhesiveness

Abstract Background Neutrophils can release pro-inflammatory cytokines and neutrophil extracellular traps (NETs), leading to vascular thrombosis. Neutrophil-platelet interaction, a major component of thrombosis, is more pronounced in inflammatory pathologies, such as heart failure (HF).
Melissa Djouani, Benjamin L. Dumont, Paul-Eduard Neagoe, Louis Villeneuve, Jean-Claude Tardif, Daniel Gagnon, Normand Racine, Michel White, Martin G. Sirois   +8 more
openaire   +1 more source

P222 | RETICULATED PLATELETS CONTRIBUTION TO TISSUE FACTOR AND TRANSFORMING GROWTH FACTOR-BETA GENERATION IN PRIMARY MYELOFIBROSIS

Haematologica
In Primary Myelifibrosis (PMF) the platelets contribute to the vascular complication and fibrosis. We focused on the reticulated immature platelets as in PMF there is an increased platelet turnover. It also is reported that the reticulated platelets (RPs)
V. Vecchio, R. Cacciola, E. Cacciola.
doaj  

ITGB3/CD61: a hub modulator and target in the tumor microenvironment.

American journal of translational research
β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 participates in reprogramming tumor metabolism, shaping the stromal and immune microenvironment, facilitating epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal ...
Chen, Zhu, Ziqing, Kong, Biao, Wang, Wen, Cheng, Anhua, Wu, Xin, Meng   +5 more
openaire   +1 more source