Results 141 to 150 of about 111,342 (306)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

EXPRESSION OF CD68 IN ORAL SQUAMOUS CELL CARCINOMA

Pakistan Journal of Physiology
Background: Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer of oral cavity. Objective of this study was to evaluate the immunohistochemical expression of CD68 in OSCC and to assess CD68 immunohistochemical expression in various grades of OSCC.
Noor Jehanzeb, Sara Ziaullah, Aysha Khitab, Irfan Ali, Mehreen Malik, Imad Ali   +5 more
openaire   +1 more source

CD68 positive macrophages express Fn14 in human injured peritoneum.

, 2014
Human peritoneum biopsies from non-infected, stable, chronic PD patients were stained with both anti-Fn14 antibody (green) and anti-CD68 antibody (red).
Luiz Stark Aroeira (260964), Gloria del Peso (405935), Maria Dolores Sanchez-Niño (303063), Rafael Selgas (260970), Teresa Bellon (531095), Manuel Lopez-Cabrera (181137), Beatriz Santamaria (5658298), Jesus Egido (2652502), Jose Jimenez-Heffernan (531096), Alberto Ortiz (108398), Luis Miguel Blanco-Colio (2333821), Marta Ruiz-Ortega (108389), Ana Belen Sanz (303062)   +12 more
core   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Comparison of Macrophage Frequency in Common Oral Cavity Reactive Lesions [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
Background and Objective: Oral reactive lesions are the most common oral disease. Recent studies have insisted on the presence of macrophages as a crucial component of oral reactive lesions’ microenvironment.
S Khalesi, SM Razavi, MP Ghazi
doaj  

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Динаміка CD68+ макрофагів інтерстиційного простору сім`яників щурів при тривалій блокаді синтезу лютеїнізуючого гормону триптореліном

, 2022
Після проведення статистичного аналізу кореляційних співвідношень між активністю ферментів циклу оксиду азоту, продукцією Sar та розповсюдженістю рецептора CD68+ у інтерстиції та судинах сім’яників на 30 день були встановлені наступні статистично значущі
Шепітько, Володимир Іванович, Стецук, Євген Валерійович   +1 more
core  

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source