Results 141 to 150 of about 117,742 (304)

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

EXPRESSION OF CD68 IN ORAL SQUAMOUS CELL CARCINOMA

Pakistan Journal of Physiology
Background: Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer of oral cavity. Objective of this study was to evaluate the immunohistochemical expression of CD68 in OSCC and to assess CD68 immunohistochemical expression in various grades of OSCC.
Noor Jehanzeb, Sara Ziaullah, Aysha Khitab, Irfan Ali, Mehreen Malik, Imad Ali   +5 more
openaire   +1 more source

HCV infection is associated with higher CD68⁺CD80⁺ and CD68⁺CD86⁺ cell frequency in the lobular areas when compared to the portal areas of the liver.

, 2016
Biopsies from HCV-infected and control individuals were stained as described in the methods. (A) CD68+CD80+, (B) CD68+CD86+ and (C) CD68+PD-L1+ cell count in the lobular and portal areas of the liver of control individuals. (D) CD68+CD80+, (E) CD68+CD86+
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Comparison of Macrophage Frequency in Common Oral Cavity Reactive Lesions [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
Background and Objective: Oral reactive lesions are the most common oral disease. Recent studies have insisted on the presence of macrophages as a crucial component of oral reactive lesions’ microenvironment.
S Khalesi, SM Razavi, MP Ghazi
doaj  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

CD68 is a candidate entry receptor for HPV16.

The putative CD68-mediated entry pathway involved interactions with TMEM106A, GPR137, RAB13, TMEM110A, and CCDC28B.  
openaire   +2 more sources

Динаміка CD68+ макрофагів інтерстиційного простору сім`яників щурів при тривалій блокаді синтезу лютеїнізуючого гормону триптореліном

, 2022
Після проведення статистичного аналізу кореляційних співвідношень між активністю ферментів циклу оксиду азоту, продукцією Sar та розповсюдженістю рецептора CD68+ у інтерстиції та судинах сім’яників на 30 день були встановлені наступні статистично значущі
Шепітько, Володимир Іванович, Стецук, Євген Валерійович   +1 more
core  

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Immunohistochemical analysis and quantification of CD68-positive cells in human lung cancer.

, 2015
Human lung cancer tissue array was stained with CD68 antibody to detect macrophages. (A) Quantification of CD68+ cells in lung cancer vs. healthy donor specimens.
Catherine Olesch (801010), Ludger Fink (5496), Andreas Weigert (801009), Katharina Ebel (801011), G-Andre Banat (801007), Aleksandra Tretyn (801008), Soni Savai Pullamsetti (224322), Jochen Wilhelm (353946), Thorsten Stiewe (257607), Friedrich Grimminger (142867), Rajkumar Savai (192633), Werner Seeger (5494)   +11 more
core   +1 more source