Results 131 to 140 of about 117,742 (304)

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

CD68 immunostaining in rats implanted with synthetic mesh.

, 2012
A. PA after 7 days and B. after 90 days implantation (- - - line around mesh filament). Brown staining indicates CD68+ macrophages. C. Percentage CD68 positive area within 50 µm radius of central mesh filament bundle. Data are mean ± SEM of n = 6 animals/
Tommy Supit (118643), Jerome A. Werkmeister (118659), Jacinta F. White (118640), John A. M. Ramshaw (118646), Sharon L. Edwards (118633), Camden Lo (118651), Daniela Ulrich (118627), Anna Rosamilia (118655), Caroline E. Gargett (118663)   +8 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

CD68 positive macrophages express Fn14 in human injured peritoneum.

, 2014
Human peritoneum biopsies from non-infected, stable, chronic PD patients were stained with both anti-Fn14 antibody (green) and anti-CD68 antibody (red).
Luiz Stark Aroeira (260964), Gloria del Peso (405935), Maria Dolores Sanchez-Niño (303063), Rafael Selgas (260970), Teresa Bellon (531095), Manuel Lopez-Cabrera (181137), Beatriz Santamaria (5658298), Jesus Egido (2652502), Jose Jimenez-Heffernan (531096), Alberto Ortiz (108398), Luis Miguel Blanco-Colio (2333821), Marta Ruiz-Ortega (108389), Ana Belen Sanz (303062)   +12 more
core   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Distribution characteristics of CD68⁺COX-2⁺ TAMs in the ovarian cancer tissue.

, 2013
(A) CD68+COX-2+ TAMs in a representative cancer tissue section from the high MUC2 expression group were shown. (B) CD68+COX-2+ TAMs in a representative cancer tissue section from the low MUC2 expression group were shown. Nuclei were stained with SYTO 40,
Xiang-jun Sun (494118), Yi-feng He (5657095), Xin Wu (10164), Qi-zhi He (494119), Mei-ying Zhang (494117), Wen Di (384960), Ting Xu (215531)   +6 more
core   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

P02.21.A PROGNOSTIC ROLE OF CD68 AND CD163 IN GLIOMAS

Neuro-Oncology
Abstract BACKGROUND Tumor-associated macrophages (TAMs) have been demonstrated to play an important role in the growth and progression of multiple types of cancer, including glioblastoma. The aim of this study is to evaluate the distribution of CD68 and CD163 markers for TAMs in glioma samples and to ...
Petrescu, G E D, Dragomir, M P, Brehar, F M, Gorgan, R M   +3 more
openaire   +2 more sources

Total CD68⁺ TAMs and their M1 and M2 subsets in the ovarian cancer tissue.

, 2013
(A) Representative MUC2 and CD68 single-immunostained and CD68/HLA-DR, CD68/iNOS, CD68/CD163, CD68/VEGF double-immunostained sections from the high MUC2 expression group.
Xiang-jun Sun (494118), Yi-feng He (5657095), Xin Wu (10164), Qi-zhi He (494119), Mei-ying Zhang (494117), Wen Di (384960), Ting Xu (215531)   +6 more
core   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source