Results 131 to 140 of about 111,342 (306)
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
, 2016 Using the automatic image analysis system (ScanScope XT; Aperio) for positive pixel count v9 algorithm, the density of CD68+ or CD163+ TAM was measured separately in the epithelium (left) and stroma (right).
Han Kwang Yang (841405) +4 more
core +1 more source
Advanced Science, EarlyView.ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
Immunohistochemical staining of meningioma tissues with the anti-CD68 antibody.
, 2013 CD68-positive cells detected within the tumor parenchyma showed reactivity in their cytoplasm and a mononuclear cell appearance, compatible with macrophages infiltrating the tumor.
Álvaro Otero (465380) +11 more
core +1 more source
Advanced Science, EarlyView.PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
P02.21.A PROGNOSTIC ROLE OF CD68 AND CD163 IN GLIOMAS
Neuro-OncologyAbstract BACKGROUND Tumor-associated macrophages (TAMs) have been demonstrated to play an important role in the growth and progression of multiple types of cancer, including glioblastoma. The aim of this study is to evaluate the distribution of CD68 and CD163 markers for TAMs in glioma samples and to ...
Petrescu, G E D +3 more
openaire +2 more sources
Immunohistochemistry stain of CD68 in the spleen.
, 2013 (A) Representative spleen sections taken from the control mice and the 29.5 mg/kg, 103.5 mg/kg and 177.5 mg/kg administered mice at 400× magnification.CD68 expression increased in the red pulp in the spleen of the SNP treated mice.
Zhiwei Sun (153761) +8 more
core +1 more source
Advanced Science, EarlyView.SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu +8 more
wiley +1 more source