Results 111 to 120 of about 117,742 (304)

CD68^−/− have abnormal morphology.

, 2013
(A) Prior to TRAP staining, osteoclasts of all three genotypes were of relatively similar size. CD68−/− osteoclasts demonstrated intracellular vacuole-like structures that were not present to such an extent in CD68-expressing cells. Scale bars are 100μm.
Robert A. Kesterson (342895), Xu Feng (342896), Jason W. Ashley (342892), Haibo Zhao (198087), Zhenqi Shi (342893), Xingsheng Li (342894)   +5 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Immunohistochemical Evaluation of CD68, β-catenin, α-SMA and Ki67 Expression in Kupffer and Parenchymal Stellate Cells Associated With Bovine Liver Lesions Leading to Fibrosis [PDF]

Archives of Razi Institute
Introduction: Liver fibrosis is a disorder resulting from numerous diseases that threaten animal life. Materials and Methods: Over two years (2021-2023), a total of 1,525 bovine livers were inspected, and common liver diseases leading to fibrosis ...
Pardis Khodagholizadeh, Amir Amniattalab
doaj   +1 more source

Representative CD3 and CD68 immunofluorescence.

, 2013
Representative CD3 (left) and CD68 (right) immunofluorescence of the distal colon from normal mice, trinitrobenzene sulfonic acid (TNBS) administration and treatment with sc. 100 µg/kg XG-102.
Thomas Herdegen (329707), Wibke Roessner (329692), Philip Rosenstiel (68103), Franziska Dierck (329691), Ivo Leuschner (161254), Christian Sina (329708), Olga Gavrilova (329700), Sevgi Eminel (329690), Sabine Kersting (329694), Kirstin Reinecke (329689), Ale Laukevicience (329702), Vicki Waetzig (329705), Ansgar Michael Chromik (329697)   +12 more
core   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Double immunostaining (NRPs vs CD68, CD163, HO-1 and DC-SIGN) and triple immunohistochemistry (CD68, CD163 and NRP-1) of lung tissue adjacent to the cancer.

, 2016
(A) Double IF showed expression of CD68, CD163 and HO-1 (Rhodamine, anti-mouse, red color) on NRP-1+(Fluorescein, anti-rabbit, green color) alveolar macrophages. White arrows showed double positive cells.
Hongxue Meng (2272915), Tomoya Kato (2124757), Mitsunori Yamakawa (641922), Suran Yang (2272906), Naing Ye Aung (2272909), Takanobu Kabasawa (2272912), Rintaro Ohe (641921)   +6 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Quantification of CD68-positive activated microglia in hAPP-J20 mice.

, 2013
CD68-positive microglia were observed in the hippocampus of (A) WT mice compared to (B) their hAPP-J20 littermates at 36 weeks of age.
Ian A. Clark (396764), Amanda L. Wright (396758), Lyndsey M. Konen (396761), Richard P. Tan (396763), Barbara Hohensinn (396760), Andrea Abdipranoto (240832), Raphael Zinn (396759), Bryce Vissel (240839), Sarah B. Beynon (396762)   +8 more
core   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source