Results 91 to 100 of about 120,442 (308)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Immunohistochemical Study of CD68 and CR3/43 in Astrocytic Gliomas

Journal of Analytical Oncology, 2012
 Diffuse and high-grade astrocytomas are invasive neoplasms which grow diffusely into the brain parenchyma. Microglia has been termed the brain's immune system, although its specific role remains uncertain. Objective of this study was to assess in a series of astrocytic neoplasms, the expression of a macrophage marker CD 68 and Major Histocompatibility
CAFFO, Maria, Caruso G, BARRESI, Valeria, Pino MA, VENZA, Mario, ALAFACI, Concetta, TOMASELLO, Francesco   +6 more
openaire   +3 more sources

Immunohistochemical analysis and quantification of CD68-positive cells in human lung cancer.

, 2015
Human lung cancer tissue array was stained with CD68 antibody to detect macrophages. (A) Quantification of CD68+ cells in lung cancer vs. healthy donor specimens.
Catherine Olesch (801010), Ludger Fink (5496), Andreas Weigert (801009), Katharina Ebel (801011), G-Andre Banat (801007), Aleksandra Tretyn (801008), Soni Savai Pullamsetti (224322), Jochen Wilhelm (353946), Thorsten Stiewe (257607), Friedrich Grimminger (142867), Rajkumar Savai (192633), Werner Seeger (5494)   +11 more
core   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Sensitivity analyses of the association between CD68+ TAMs and prognosis.

, 2019
(A) Sensitivity analysis of the association between CD68+ TAMs in IT and OS; (B) Sensitivity analysis of the association between CD68+ TAMs in PT and OS.
Yan Qian (388125), Wei Ding (690), Wenbo Xue (1790827), Yibo Wang (304377), Peng Jiang (16544), Xuezhong Xu (688748), Yulin Tan (1771855)   +6 more
core   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Tumor Microenvironment Modulation by Tumor-Associated Macrophages: Implications for Neoadjuvant Chemotherapy Response in Breast Cancer

Breast Cancer: Targets and Therapy
Gizem Oner,1– 3 Marleen Marguerite Praet,4 Hans Stoop,4 Gayathri R Devi,5 Nuh Zafer Canturk,3 Sevilay Altintas,1,2 Christophe Van Berckelaer,1,2 Zwi Berneman,6 Wiebren Tjalma,1,2 Senada Koljenovic,4 Peter A van Dam1,2 1Multidisciplinary Oncologic Centre ...
Oner G, Praet MM, Stoop H, Devi GR, Canturk NZ, Altintas S, Van Berckelaer C, Berneman Z, Tjalma W, Koljenovic S, van Dam PA   +10 more
doaj  

The role of CD68+ macrophage in classical Hodgkin lymphoma patients from Egypt

Diagnostic Pathology, 2020
Background CD68+ tumor-associated macrophages (TAM) play an important role in the progression of classical Hodgkin lymphoma (cHL). We assessed the role of CD20 and CD68 + TAM in a cohort of cHL patients from Egypt and correlated the number of CD68 ...
Osama Mohamed, Ahmed El Bastawisy, Nasr Allahlobi, Mona S. Abdellateif, Abdel Rahman N. Zekri, Sabry Shaarawy, Zeinab Korany, Marwa Mohanad, Abeer A. Bahnassy   +8 more
doaj   +1 more source