Results 91 to 100 of about 117,742 (304)

Immunohistochemical Study of CD68 and CR3/43 in Astrocytic Gliomas

Journal of Analytical Oncology, 2012
 Diffuse and high-grade astrocytomas are invasive neoplasms which grow diffusely into the brain parenchyma. Microglia has been termed the brain's immune system, although its specific role remains uncertain. Objective of this study was to assess in a series of astrocytic neoplasms, the expression of a macrophage marker CD 68 and Major Histocompatibility
CAFFO, Maria, Caruso G, BARRESI, Valeria, Pino MA, VENZA, Mario, ALAFACI, Concetta, TOMASELLO, Francesco   +6 more
openaire   +3 more sources

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Prognostic Implications of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Journal of Orofacial Sciences
Introduction: Tumor-associated macrophages (TAMs) are the major cellular component in the tumor microenvironment of oral squamous cell carcinoma (OSCC). Several studies have been put forward to assess the role of TAMs in the prognostication of OSCC.
Surya Surendran L, Anna Palliath Joseph, Varun B Raghavan Pillai, Vinej Somaraj, Sunjith Sudhakar, Amitha Mohan   +5 more
doaj   +1 more source

Immunohistochemical staining for CD68.

, 2018
CD68+ macrophages are located in the renal interstitium indicated by white arrow, blood vessels indicated by black arrow or the lumen of the renal tubules indicated by red arrow (×400).
LiXia Zhang (3178137), XuDong Huang (3178140), XinJun Yang (3178149), YunShuang Chen (3178146), Wei Zhao (14321), Chao Zhang (51048), LiHui Wang (3178143), GuangLi Wu (3178152), JingHua Wang (3178155)   +8 more
core   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Sensitivity analyses of the association between CD68+ TAMs and prognosis.

, 2019
(A) Sensitivity analysis of the association between CD68+ TAMs in IT and OS; (B) Sensitivity analysis of the association between CD68+ TAMs in PT and OS.
Yan Qian (388125), Wei Ding (690), Wenbo Xue (1790827), Yibo Wang (304377), Peng Jiang (16544), Xuezhong Xu (688748), Yulin Tan (1771855)   +6 more
core   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Cardiomyocytes represent the contractile units of the myocardium, while the maintenance and renewal of the extracellular matrix is a function of fibroblasts.
T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib   +8 more
doaj   +1 more source

Localization patterns of CD68-positive macrophage populations across CRCLM specimens.

, 2014
(A) Representative images of three major distribution patterns are shown: (a) accumulation of CD68-positive macrophages lining the tumor body within the tumor – liver border sub-region; (b) CD68-positive rim bounding tumor parts and differentiating them ...
Erika Jensen-Jarolim (203031), Judith Stift (313976), Erika Bajna (203017), Anastasia Meshcheryakova (573898), Denise Heiden (573901), Thomas Grünberger (573903), Dietmar Tamandl (573899), Stefan Stremitzer (573902), Diana Mechtcheriakova (203012), Martina Mittlboeck (573900), Martin Svoboda (203023), Michael Bergmann (137488)   +11 more
core   +1 more source