Results 71 to 80 of about 111,342 (306)

The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Cardiomyocytes represent the contractile units of the myocardium, while the maintenance and renewal of the extracellular matrix is a function of fibroblasts.
T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib   +8 more
doaj   +1 more source

Representative immunostaining of CD8, CD68, and CD169.

, 2016
Tumor infiltrating CD8+ lymphocytes were evaluated in primary cancer tissues, while CD68+ and CD169+ sinus macrophages were evaluated in RLNs (A). Representative images of CD8 (B) and of CD68 and CD169 (C) immunostaining. HE, Hematoxylin-Eosin staining.
Yutaka Yamamoto (486365), Motohiro Takeya (414255), Takuya Shiota (3353981), Hirotaka Iwase (32869), Yoshihiro Komohara (414247), Koji Ohnishi (516953), Mutsuko Yamamoto-Ibusuki (486364), Yuko Miyasato (3353984)   +7 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

CD68 Immunostaining in the Evaluation of Chronic Histiocytic Intervillositis

Archives of Pathology & Laboratory Medicine, 2012
Context .—Chronic histiocytic intervillositis is an uncommon and poorly recognized lesion associated with poor perinatal outcomes, including intrauterine growth retardation and stillbirth. It has a high recurrence rate.
openaire   +2 more sources

Rod-microglia had different stages of CD68 staining.

, 2013
Iba-1+ and CD68+ cells. Retinal whole-mounts. With respect both to morphological features and to CD68 immunostaining patterns, three stages of rod-like microglia were detected: (A1-A3) rod-like microglia with elongated cell bodies and processes ...
Alberto Triviño (499408), Beatriz I. Gallego (499404), Marcelino Avilés-Trigueros (499406), Francisco J. Valiente-Soriano (499405), Rosa de Hoz (419547), Manuel Vidal-Sanz (93132), Juan J. Salazar (419545), Ana I. Ramírez (419550), José M. Ramírez (419551), Maria P. Villegas-Perez (499407), Blanca Rojas (419549)   +10 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city

Zanco Journal of Medical Sciences
Background and objective: The aims of the present research were to study the clinicopathological features of adult classical Hodgkin lymphoma (cHL) in Hawler city and to evaluate the significance of immunohistochemical expression of CD68 positive tumor ...
Tenya Tariq Abdulhameed, Salah Abubakir Ali, Amin Aziz Bakir   +2 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Liver macrophages play a pivotal role in maintaining the homeostasis of the liver and the entire body, they may be classified into three categories based on their origin.
M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych   +9 more
doaj   +1 more source

Role of CD68 in tumor immunity and prognosis prediction in pan-cancer

Scientific Reports, 2022
CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression
Jingwei Zhang, Shuwang Li, Fangkun Liu, Kui Yang   +3 more
doaj   +1 more source