Results 81 to 90 of about 117,742 (304)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Pathomorphological brain changes due to coronavirus disease 2019 (COVID-19)

Patologìâ
Aim: To investigate the pathomorphological changes in the brains of individuals who died from complications of coronavirus disease (COVID-19) and to identify the neuropathological features associated with COVID-19. Materials and methods.
L. I. Volos, H. L. Stoliar
doaj   +1 more source

Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats

PLOS ONE, 2015
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost.
Cascao, Rita, Vidal, Bruno, Lopes, Inês, Paisana, Eunice, Rino, José, Moita, Luis, Fonseca, João Eurico   +6 more
openaire   +6 more sources

Immunohistochemistry stain of CD68 in the liver.

, 2013
(A) Representative liver sections taken from control mice and 29.5 mg/kg, 103.5 mg/kg and 177.5 mg/kg administered mice at 400× magnification. Hepatic granulomas showed strong positive signals for CD68 in the SNP treated mice. Arrows denote CD68 positive
Zhiwei Sun (153761), Minghua Jin (402267), Yanbo Li (402269), Yang Yu (4292), Yang Li (7082), Junchao Duan (402270), Wen Wang (6570), Zhongjun Du (402268), Yongbo Yu (402271)   +8 more
core   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Pleomorphic rhabdomyosarcoma: a case study

Vestnik Dermatologii i Venerologii, 2017
Pleomorphic rhabdomyosarcoma of the skin is a fast progressing tumor with high risk of development of lymphogenous and hematogenous metastasis, low survival rates and complex diagnostics. this clinical case describes the application of typing tumor cells
A. V. Kozlova, V. M. Kazakov, L. N. Kokh, T. G. Ruksha   +3 more
doaj   +1 more source

Significance and Regulation of CD68 Expression in the Osteoclast [PDF]

, 2011
The mucin-like Lysosome Associated Membrane Protein (LAMP) family member CD68 is a primarily myeloid lineage restricted transmembrane protein that is expressed in macrophages and osteoclasts.
Ashley, Jason Waid
core  

Immunohistochemistry stain of CD68 in the lung.

, 2013
(A) Representative lung sections taken from the control mice and the 29.5 kg, 103.5 mg/kg and 177.5 administered mice at 400× magnification. Positive signals of CD68 expression were occasionally observed in suspected granuloma in the lung sections from ...
Zhiwei Sun (153761), Minghua Jin (402267), Yanbo Li (402269), Yang Yu (4292), Yang Li (7082), Junchao Duan (402270), Wen Wang (6570), Zhongjun Du (402268), Yongbo Yu (402271)   +8 more
core   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Immunohistochemical Assessment of Proliferation, Angiogenesis, and Viral Markers in Recurrent Laryngeal Papillomatosis [PDF]

Modern Medicine
Recurrent laryngeal papillomatosis (RLP) is a benign but clinically aggressive condition, characterized by frequent recurrences and significant morbidity.
Daniela CERNEV, Lilian SAPTEFRATI, Valeriu DAVID, Vasile CABAC   +3 more
doaj   +1 more source