Results 101 to 110 of about 111,342 (306)

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

Biomedical Papers, 2018
Aims: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in
Marek Handl, Marketa Hermanova, Sylva Hotarkova, Jiri Jarkovsky, Peter Mudry, Tetiana Shatokhina, Marcela Vesela, Jaroslav Sterba, Iva Zambo   +8 more
doaj   +1 more source

The role of CD68+ macrophage in classical Hodgkin lymphoma patients from Egypt

Diagnostic Pathology, 2020
Background CD68+ tumor-associated macrophages (TAM) play an important role in the progression of classical Hodgkin lymphoma (cHL). We assessed the role of CD20 and CD68 + TAM in a cohort of cHL patients from Egypt and correlated the number of CD68 ...
Osama Mohamed, Ahmed El Bastawisy, Nasr Allahlobi, Mona S. Abdellateif, Abdel Rahman N. Zekri, Sabry Shaarawy, Zeinab Korany, Marwa Mohanad, Abeer A. Bahnassy   +8 more
doaj   +1 more source

Sensitivity analyses of the association between CD68+ TAMs and prognosis.

, 2019
(A) Sensitivity analysis of the association between CD68+ TAMs in IT and OS; (B) Sensitivity analysis of the association between CD68+ TAMs in PT and OS.
Yan Qian (388125), Wei Ding (690), Wenbo Xue (1790827), Yibo Wang (304377), Peng Jiang (16544), Xuezhong Xu (688748), Yulin Tan (1771855)   +6 more
core   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Immunohistochemical Evaluation of CD68, β-catenin, α-SMA and Ki67 Expression in Kupffer and Parenchymal Stellate Cells Associated With Bovine Liver Lesions Leading to Fibrosis [PDF]

Archives of Razi Institute
Introduction: Liver fibrosis is a disorder resulting from numerous diseases that threaten animal life. Materials and Methods: Over two years (2021-2023), a total of 1,525 bovine livers were inspected, and common liver diseases leading to fibrosis ...
Pardis Khodagholizadeh, Amir Amniattalab
doaj   +1 more source

CD68^−/− have abnormal morphology.

, 2013
(A) Prior to TRAP staining, osteoclasts of all three genotypes were of relatively similar size. CD68−/− osteoclasts demonstrated intracellular vacuole-like structures that were not present to such an extent in CD68-expressing cells. Scale bars are 100μm.
Robert A. Kesterson (342895), Xu Feng (342896), Jason W. Ashley (342892), Haibo Zhao (198087), Zhenqi Shi (342893), Xingsheng Li (342894)   +5 more
core   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Immunohistochemical Assessment of Proliferation, Angiogenesis, and Viral Markers in Recurrent Laryngeal Papillomatosis [PDF]

Modern Medicine
Recurrent laryngeal papillomatosis (RLP) is a benign but clinically aggressive condition, characterized by frequent recurrences and significant morbidity.
Daniela CERNEV, Lilian SAPTEFRATI, Valeriu DAVID, Vasile CABAC   +3 more
doaj   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source