Results 101 to 110 of about 117,742 (304)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

The role of CD68+ macrophage in classical Hodgkin lymphoma patients from Egypt

Diagnostic Pathology, 2020
Background CD68+ tumor-associated macrophages (TAM) play an important role in the progression of classical Hodgkin lymphoma (cHL). We assessed the role of CD20 and CD68 + TAM in a cohort of cHL patients from Egypt and correlated the number of CD68 ...
Osama Mohamed, Ahmed El Bastawisy, Nasr Allahlobi, Mona S. Abdellateif, Abdel Rahman N. Zekri, Sabry Shaarawy, Zeinab Korany, Marwa Mohanad, Abeer A. Bahnassy   +8 more
doaj   +1 more source

[Investigation of CD68 positive monocytes/macrophage(CD68+ Mo/M phi) in urine and infiltrated tissue of various kidney diseases in children].

Nihon Jinzo Gakkai shi, 2002
In order to investigate the participation of monocytes/macrophages(Mo/M phi) in the progression of various kidney diseases of children, Mo/M phi in urine and that infiltrating renal tissue were both measured as the number of CD68 positive Mo/M phi (CD68+ Mo/M phi), using anti-CD68 antibody.
SAITOH, Akira, IKOMA, Masaaki, KAMIYAMA, Chieko, DOT, Keiji, KOITABASHI, Yasushi   +4 more
openaire   +2 more sources

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city

Zanco Journal of Medical Sciences
Background and objective: The aims of the present research were to study the clinicopathological features of adult classical Hodgkin lymphoma (cHL) in Hawler city and to evaluate the significance of immunohistochemical expression of CD68 positive tumor ...
Tenya Tariq Abdulhameed, Salah Abubakir Ali, Amin Aziz Bakir   +2 more
doaj   +1 more source

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

Biomedical Papers, 2018
Aims: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in
Marek Handl, Marketa Hermanova, Sylva Hotarkova, Jiri Jarkovsky, Peter Mudry, Tetiana Shatokhina, Marcela Vesela, Jaroslav Sterba, Iva Zambo   +8 more
doaj   +1 more source

IL-1β and IL-1ra mRNA in CD68 positive cells.

, 2013
Expression of IL-1β and IL-1ra mRNA in CD68 positive activated macrophages/microglial cells during the first disease phase of EAE. (A, B) IL-1β mRNA (black grains) combined with CD68 immunoreactivity (brown) in the vestibular nucleus of the brain stem ...
Anne Wierinckx (164065), Marloes Prins (501723), Fred J. H. Tilders (501725), Rob Binnekade (221991), John G. J. M. Bol (204893), Charlotta Eriksson (501724), Anne-Marie Van Dam (5657257)   +6 more
core   +1 more source

Inhibition of vericiguat on CD16 and CD68 expression.

, 2023
(A) Representative photomicrographs of CD16 and CD68 staining (scale bar: 50 μm). N = 4.(B) Quantitative analysis of CD16 (+) area.(C) Quantitative analysis of CD68 (+) area.
Yang Shen (66591), Weida Zhu (4352272), Wenbing Liu (17696630), Yue Ben (2363395)   +3 more
core   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Liver macrophages play a pivotal role in maintaining the homeostasis of the liver and the entire body, they may be classified into three categories based on their origin.
M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych   +9 more
doaj   +1 more source