Results 61 to 70 of about 117,742 (304)

HCV infection is associated with higher CD68⁺CD80⁺ cell frequency than that of CD68⁺CD86⁺ and CD68⁺PD-L1⁺ cells in the lobular areas of the liver.

, 2016
Biopsies from HCV-infected individuals were stained with mouse anti-human CD68 and rabbit anti-human CD80, CD86 or PD-L1 Abs. The count of CD68+CD80+, CD68+CD86+ and CD68+PD-L1+ cells in the lobular (A) and the total (lobular and portal; B) areas are ...
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Histopathological and immunohistochemical study in the anterior and posterior cruciate ligament of the knee with rheumatoid arthritis in Iraqi patients

Acta Marisiensis - Seria Medica
Background: Rheumatoid arthritis (RA) causes structural changes and inflammatory responses which damage the knee tissues that include the cruciate ligaments.
Chaloob Amal Kadhem, AL-Sharqi Sahar A. H.   +1 more
doaj   +1 more source

Representative immunostaining of CD8, CD68, and CD169.

, 2016
Tumor infiltrating CD8+ lymphocytes were evaluated in primary cancer tissues, while CD68+ and CD169+ sinus macrophages were evaluated in RLNs (A). Representative images of CD8 (B) and of CD68 and CD169 (C) immunostaining. HE, Hematoxylin-Eosin staining.
Yutaka Yamamoto (486365), Motohiro Takeya (414255), Takuya Shiota (3353981), Hirotaka Iwase (32869), Yoshihiro Komohara (414247), Koji Ohnishi (516953), Mutsuko Yamamoto-Ibusuki (486364), Yuko Miyasato (3353984)   +7 more
core   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Tumor necrosis and infiltrating macrophages predict survival after curative resection for cholangiocarcinoma

OncoImmunology, 2017
Background. Tumor necrosis as well as tumor-associated macrophages (TAMs) in the tumor invasive front (TIF) have been suggested to have a prognostic value in selected solid tumors, inclusive hilar cholangiocarcinoma.
Georgi Atanasov, Corinna Dietel, Linda Feldbrügge, Christian Benzing, Felix Krenzien, Andreas Brandl, Elli Mann, Julianna Paulina Englisch, Katrin Schierle, Simon C. Robson, Katrin Splith, Mehmet Haluk Morgul, Anja Reutzel-Selke, Sven Jonas, Andreas Pascher, Marcus Bahra, Johann Pratschke, Moritz Schmelzle   +17 more
doaj   +1 more source

IF staining CD68 v1

This protocol details the CD68 IF staining of free floating sagittal sections from 2 month old mouse brains.
Eduard Bentea, Hanne Dhondt, Aisha Sati
openaire   +1 more source

CD68, CD80, CD86 and PD-L1 staining in liver biopsies.

, 2016
Biopsies from HBV-infected and control individuals were stained with mouse anti-human CD68 and rabbit anti-human CD80, CD86 or PD-L1 Abs. Representative photomicrographs showing (A) CD68 red staining indicating CD68+ cells and (B-D) CD80, CD86 or PD-L1 ...
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source