Results 61 to 70 of about 111,342 (306)

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Prognostic Implications of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Journal of Orofacial Sciences
Introduction: Tumor-associated macrophages (TAMs) are the major cellular component in the tumor microenvironment of oral squamous cell carcinoma (OSCC). Several studies have been put forward to assess the role of TAMs in the prognostication of OSCC.
Surya Surendran L, Anna Palliath Joseph, Varun B Raghavan Pillai, Vinej Somaraj, Sunjith Sudhakar, Amitha Mohan   +5 more
doaj   +1 more source

CD68, CD80, CD86 and PD-L1 staining in liver biopsies.

, 2016
Biopsies from HBV-infected and control individuals were stained with mouse anti-human CD68 and rabbit anti-human CD80, CD86 or PD-L1 Abs. Representative photomicrographs showing (A) CD68 red staining indicating CD68+ cells and (B-D) CD80, CD86 or PD-L1 ...
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

HCV infection is associated with higher CD68⁺CD80⁺ cell frequency than that of CD68⁺CD86⁺ and CD68⁺PD-L1⁺ cells in the lobular areas of the liver.

, 2016
Biopsies from HCV-infected individuals were stained with mouse anti-human CD68 and rabbit anti-human CD80, CD86 or PD-L1 Abs. The count of CD68+CD80+, CD68+CD86+ and CD68+PD-L1+ cells in the lobular (A) and the total (lobular and portal; B) areas are ...
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Histopathological and immunohistochemical study in the anterior and posterior cruciate ligament of the knee with rheumatoid arthritis in Iraqi patients

Acta Marisiensis - Seria Medica
Background: Rheumatoid arthritis (RA) causes structural changes and inflammatory responses which damage the knee tissues that include the cruciate ligaments.
Chaloob Amal Kadhem, AL-Sharqi Sahar A. H.   +1 more
doaj   +1 more source

Prognostic value of CD3, CD4, CD8 and CD 68 in high-grade diffuse astrocytomas, the transformation of an immune profile in recurrent tumors

Journal of Education, Health and Sport, 2018
Introduction and purpose. Immunotherapy has shown good results in the treatment of other cancers. There is a lack of data about the role of the immune system in high-grade glioma development. Moreover, the available data is ambiguous.
Taisia Chertenko, Irina Yakovtsova
doaj   +1 more source

Baseline characteristics of CD68-Tg mice.

, 2014
Baseline characteristics were measured in WT, A2bAR KO, and CD68-Tg mice at 12 weeks of age. A. Glucose clearance in the blood post glucose overload (n = 12/group). Data in a.
Anna S. Eisenstein (571929), Shannon Carroll (571930), Milka Koupenova (148755), Katya Ravid (65761), Hillary Johnston-Cox (148752)   +4 more
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source