Results 91 to 100 of about 35,344 (261)

Effect of growth hormone secretagogue receptor 1a knockout on the expression of microglial cells in the hypothalamus of mice [PDF]

精准医学杂志
Objective To investigate the effect of growth hormone secretagogue receptor 1a (GHS-R1a) knockout on the expression of microglial cells in the hypothalamus of mice.
DENG Mingru, ZHONG Ping, XU Jing, LIU Junru, XIONG Xingxing, YUAN Haicheng
doaj   +1 more source

IL-10: the master regulator of immunity to infection.

, 2008
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., Riley, Eleanor M.   +5 more
core   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

A Study of Macrophages, Macrophage-related Cells, and Endothelial Adhesion Molecules in Recurrent Aphthous Ulcers in HIV-positive Patients

, 1993
The purpose of this immunohistochemical study was to investigate the presence and distribution of macrophages (CDllc+ and CD68+) and macrophage-related dendritic cells (factor XIIIa+ and CD36+) in early and late aphthous ulcers associated with HIV ...
D.W. Richards, J.S. Greenspan, J.A. Regezi, L.A. Macphail   +3 more
core   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice.

, 2002
Macrophage foam cells are integral in the development of atherosclerotic lesions. Gene expression analysis of lesional macrophage foam cells is complicated by the cellular heterogeneity of atherosclerotic plaque and the presence of lesions of various ...
Rong, JX, Breslow, JL, Trogan, E, Choudhury, RP, Dansky, HM, Fisher, EA   +5 more
core   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model

Journal of Translational Medicine, 2011
Background This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury. Methods Adult male Sprague-Dawley (SD) rats (n = 24)
Fu Morgan, Chua Sarah, Chang Li-Teh, Kao Ying-Hsien, Tsai Tzu-Hsien, Lin Yu-Chun, Yen Chia-Hung, Sun Cheuk-Kwan, Ko Sheung-Fat, Leu Steve, Yip Hon-Kan   +10 more
doaj   +1 more source

mC4 overexpression enhanced microglia engulfment of postsynaptic PSD-95.

, 2020
(A-D) Representative confocal image (60X) showing PSD-95 located within microglial lysosomes in P21 mice for control (A-B) and mC4 conditions (C-D). Single z-plane shown. Scale bar = 5 μm. Magenta: microglia (“MG) (Iba1). Red: lysosomes (CD68).
Lisa N. Kretsge (8299140), Yenyu Liu (8299164), Alberto Cruz-Martín (331261), SaraAnn Rosenthal (8299158), Jungjoon Lee (2249953), Kevin Liu Kot (8299161), Frances S. Hausmann (8299155), Borislav Dejanovic (598187), Rhushikesh A. Phadke (8299137), Elena R. Newmark (8299152), Giovanna Antognetti (8299146), Ashley L. Comer (8299128), Thanh P. H. Nguyen (8299143), James P. Gilbert (8299149), Tushare Jinadasa (8299131), William W. Yen (8299167), Balaji Sriram (8299134)   +16 more
core   +1 more source