Results 81 to 90 of about 35,344 (261)

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Microglia derived from human induced pluripotent stem cells are regulated by osteopontin, an endogenous extracellular matrix protein maintaining immune homeostasis

Frontiers in Neuroscience
IntroductionMicroglia are brain-resident immune cells responsible for maintaining homeostasis, coordinating responses to injury and disease, and mediating regeneration.
Daniel Navin Olschewski, Daniel Navin Olschewski, Anna Maria Koenig, Helena Mira Nerone, Elena Gross, Tomo Šarić, Sabine Ulrike Vay, Michael Schroeter, Michael Schroeter, Gereon R. Fink, Gereon R. Fink, Maria Adele Rueger, Maria Adele Rueger   +12 more
doaj   +1 more source

Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways

Cells, 2020
The development of osteoarthritis (OA) is characterized by synovial inflammation and the upregulation of vascular cell adhesion molecule type 1 (VCAM-1) in human osteoarthritis synovial fibroblasts (OASFs).
Wei-Cheng Chen, Chih-Yang Lin, Shu-Jui Kuo, Shan-Chi Liu, Yung-Chang Lu, Yen-Ling Chen, Shih-Wei Wang, Chih-Hsin Tang   +7 more
doaj   +1 more source

Immunohistochemical expression of CD3, CD20, CD45, CD68 and bcl-2 in oral squamous cell carcinoma

, 2010
To study the main processes involved in oral squamous cell carcinoma (OSCC): apoptosis and inflammation.The immunohistochemical expression of bcl-2, CD3, CD20, CD45 and CD68 were studied by standard linked streptavidin-biotin horseradish peroxidase ...
T. Pieramici, L. D. Alberti, P. Mazzotta, A. Santoro, L. L. Muzio, C. Rubini, P. Bufo, A. Mazzotta, CARINCI, Francesco, L. L. Russo   +9 more
core  

Real-Time PCR Primers.

, 2013
The following forward and reverse sequences of primers were used in real-time PCR. CD68: cluster of differentiation 68; Iba1: ionized calcium binding adaptor molecule-1; MCP1: monocyte chemoattractant protein 1; pro-IL-1β: pro-interleukin-1β; TNFα: tumor
Gyongyi Szabo (128056), Dora Lippai (443719), Evelyn A. Kurt-Jones (127827), Shashi Bala (128053), Timea Csak (361522)   +4 more
core   +1 more source

DataSheet1_Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects.DOCX

, 2021
Bazi Bushen capsule (BZBS), as a Chinese medicine used to relieve fatigue, has been proven effective for the treatment of atherogenesis through antilipid effects. To investigate the potential mechanism of BZBS in the anti-atherosclerotic effect, Ovx/ApoE-
Dan Huang (122168), Juexiao Gong (11025501), Xindong Wang (4396873), Junqing Liang (5107103), Yanfei Song (11025504), Cong Wei (695530), Linsheng Liu (141846), Yiyan Zhang (9211388), Yunhong Zhu (2936163)   +8 more
core   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

EXPRESSION OF IONIZED CALCIUM-BINDING ADAPTOR MOLECULE-1 (Iba-1) AND CD68 IN EXPERIMENTAL DIABETIC RETINOPATHY AND INFLUENCE OF ITS BLOCKADE OF CELLULAR PROTEIN KINASE

Medical Science of Ukraine (MSU)
Background. In the development of diabetic retinopathy (DR), an important role belongs to the signaling pathways of cellular protein kinases, which implement the effects of external factors. Their blockade is a reasonable measure to prevent the development of DR, which, probably, can be implemented through inhibition of the pro-inflammatory role of ...
openaire   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Tumor-Associated CD163+ M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer

Cancer Management and Research, 2020
Fan Guo,1,2,* Yang-chun Feng,1,2,* Gang Zhao,3 Ran Zhang,4 Zhen-zhen Cheng,1 Wei-na Kong,1,2 Hui-li Wu,1 Bin Xu,1 Xiang Lv,1 Xiu-min Ma1,2 1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia ...
Guo F, Feng Y, Zhao G, Zhang R, Cheng Z, Kong W, Wu H, Xu B, Lv X, Ma X   +9 more
doaj