Results 31 to 40 of about 35,344 (261)

Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study

Journal of Translational Medicine, 2017
Background The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD).
Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo, Alberto Cremonesi   +16 more
doaj   +1 more source

Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]

, 2010
Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher, Helen Williams, Cartwright, A, John HH Williams, Andrew Filer, Schmutz, Caroline, Oliver Haworth, Filer, Andrew, Mike Salmon, Haworth, O, Buckley, Christopher D., Alison Cartwright, Christopher D Buckley, Schmutz, C, Williams, John H. H., Middleton, J, Haworth, Oliver, Buckley, CD, Williams, JH, Cartwright, Alison, Caroline Schmutz, Williams, HJ, Middleton, Jim F., Williams, Helen, Salmon, Mike, Filer, A, Salmon, M, Williams, J, Williams, H, Middleton, Jim F S, Jim Middleton   +30 more
core   +1 more source

Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats [PDF]

, 2023
OBJECTIVE: Carbon tetrachloride (CCl4 ) is a non-polar molecule used in industry in grain curing, insect-killing and especially in the production of chlorofluorocarbons.
Yılmaz, H., Bahçeci, İlkay, İbik, Y.E., Mercantepe, Tolga, Duran, Ömer Faruk, Tümkaya, Levent, Arslan, Nurgül   +6 more
core   +1 more source

Combined Positive Score for Programmed Death Ligand-1 Expression and Inflammatory Microenvironment in Gastrointestinal Stromal Tumors

Medicina, 2022
Background and Objectives: GISTs are the most frequent type of mesenchymal neoplasm of the digestive tract. The prognosis is mainly determined by tumor dimensions, mitotic rate and location, but other less well-documented factors can influence evolution ...
Vlad Herlea, Alexandra Roșulescu, Violeta Claudia Calotă, Vlad Croitoru, Elena Stoica Mustafa, Cătălin Vasilescu, Sorin Alexandrescu, Traian Dumitrașcu, Irinel Popescu, Simona Olimpia Dima, Maria Sajin   +10 more
doaj   +1 more source

Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation

Gastroenterology Research and Practice, 2017
Background and Aim. Extended liver radiofrequency ablation (RFA) has been shown to disrupt gut barrier integrity with subsequent bacterial translocation.
Petros Ypsilantis, Maria Lambropoulou, Antonios Evagellou, Nikolaos Papadopoulos, Constantinos Simopoulos   +4 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency

Frontiers in Immunology, 2020
Retinitis Pigmentosa (RP) is a group of inherited retinal diseases characterized by progressive loss of rod followed by cone photoreceptors. An especially early onset form of RP with blindness in teenage years is caused by mutations in mertk, the gene ...
Deborah S. Lew, Francesca Mazzoni, Silvia C. Finnemann   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The Intrahepatic Expression and Distribution of BTLA and its Ligand HVEM in patients with HBV-related acute-on-chronic liver failure

Diagnostic Pathology, 2012
Objective It has been demonstrated that signals from the inhibitory receptor B and T lymphocyte attenuator (BTLA) are involved in regulating the pathogenesis of infectious diseases.
Xu Huan, Cao Dayan, Guo Guoning, Ruan Zhihua, Wu Yuzhang, Chen Yongwen   +5 more
doaj   +1 more source

PARP1 is required for adhesion molecule expression in atherogenesis [PDF]

, 2008
AIMS: Atherosclerosis is the leading cause of death in Western societies and a chronic inflammatory disease. However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1)
Mach, François, Stähli, Barbara E; https://orcid.org/, Stähli, Barbara E, Camici, Giovanni G., Hottiger, Michael O., Hassa, Paul O, Matter, Christian M., Matter, Christian M; https://orcid.org/, Gersbach, Monika, Odermatt, Bernhard, Tanner, Felix C., Hottiger, Michael O; https://orcid.org/, Hassa, Paul O., Stähli, Barbara E., Lüscher, Thomas F, Lüscher, Thomas F., Tanner, Felix C, Tanner, Felix C; https://orcid.org/, Borén, Jan, Hottiger, Michael O, Camici, Giovanni G, Matter, Christian M, Borén, Jan,, von Lukowicz, Tobias, Braunersreuther, Vincent, Lohmann, Christine, Lüscher, Thomas F; https://orcid.org/, Mach, François; https://orcid.org/, Camici, Giovanni G; https://orcid.org/   +28 more
core   +1 more source