Results 11 to 20 of about 36,435 (217)

The germline HLA-A02B62 supertype is associated with a PD-L1-positive tumour immune microenvironment and poor prognosis in stage I lung cancer

Heliyon, 2023
Background: Germline HLA class I molecule supertypes are shown to correlate with response to anti-PD-1 therapy. Here, we investigate the significance of germline HLA-A and HLA-B supertypes in tumour microenvironment of non-small-cell lung cancer. Methods:
Ruijiang Lin, Xiaohua Chen, Fei Su, Hongbin Wang, Biao Han, Yanhui Chen, Cuixiang Zhang, Minjie Ma   +7 more
doaj   +1 more source

Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway

BMC Cancer, 2020
Background Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are correlated with poor HGSOC survival
Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski, Pamela K. Kreeger   +7 more
doaj   +1 more source

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

Immunity, Inflammation and Disease, 2023
Background and Aim Small ubiquitin–like modifier (SUMO)‐specific protease (SENP)3 is a protease molecule that responds to reactive oxygen species (ROS) with high sensitivity.
Ximing Bao, Bin Liu, Yongquan Jiang, Tingting Feng, Wanxin Cao, Jiali Shi, Yiming Jiang, Xiaorui Chen, Jie Yang, Jiping Li, Zheng Zhou   +10 more
doaj   +1 more source

High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis

Frontiers in Oncology, 2021
BackgroundLymphoma-associated macrophages (LAMs) are key components in the lymphoma microenvironment, which may impact disease progression and response to therapy. There are two major subtypes of LAMs, CD68+ M1 and CD163+ M2.
Philippa Li, Ji Yuan, Ji Yuan, Fahad Shabbir Ahmed, Fahad Shabbir Ahmed, Austin McHenry, Kai Fu, Kai Fu, Guohua Yu, Guohua Yu, Hongxia Cheng, Hongxia Cheng, Mina L. Xu, David L. Rimm, Zenggang Pan   +14 more
doaj   +1 more source

Monocyte/macrophage and T-cell infiltrates in peritoneum of patients with ovarian cancer or benign pelvic disease

Journal of Translational Medicine, 2006
Background We previously showed that tumor-free peritoneum of patients with epithelial ovarian cancer (EOC) exhibited enhanced expression of several inflammatory response genes compared to peritoneum of benign disease.
Ma Qing, Mueller Peter, Bassett Roland L, Patenia Rebecca, Deavers Michael, Wang Xipeng, Wang Ena, Freedman Ralph S   +7 more
doaj   +1 more source

Age-Related Hearing Loss Is Accompanied by Chronic Inflammation in the Cochlea and the Cochlear Nucleus

Frontiers in Aging Neuroscience, 2022
Age-related hearing loss (ARHL) is a major hearing impairment characterized by pathological changes in both the peripheral and central auditory systems.
Benjamin J. Seicol, Benjamin J. Seicol, Shengyin Lin, Ruili Xie, Ruili Xie   +4 more
doaj   +1 more source

SOD3 reduces inflammatory cell migration by regulating adhesion molecule and cytokine expression. [PDF]

PLoS ONE, 2009
Inflammatory cell migration characteristic of ischemic damages has a dual role providing the tissue with factors needed for tissue injury recovery simultaneously causing deleterious development depending on the quality and the quantity of infiltrated ...
Juha P Laurila, Lilja E Laatikainen, Maria D Castellone, Mikko O Laukkanen   +3 more
doaj   +1 more source

Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer

Frontiers in Immunology, 2022
CD147 plays an important role in promoting tumor proliferation and inhibiting cancer cell apoptosis in the tumor microenvironment. However, the mechanisms by which CD147 is involved in tumorigenesis remains unclear. This study systematically analyzed the
Jingwei Zhang, Jingwei Zhang, Zeyu Wang, Zeyu Wang, Xun Zhang, Xun Zhang, Ziyu Dai, Ziyu Dai, Wen Zhi-Peng, Jing Yu, Yun Peng, Yun Peng, Wantao Wu, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Songshan Feng, Songshan Feng, Songshan Feng, Songshan Feng, Hao Zhang, Hao Zhang, Quan Cheng, Quan Cheng, Quan Cheng, Quan Cheng   +26 more
doaj   +1 more source

Expression of ICAM-1, TNF-α, NFκB, and MAP kinase in tubers of the tuberous sclerosis complex

Neurobiology of Disease, 2003
Individuals affected with tuberous sclerosis complex (TSC) develop cortical tubers characterized by disorganized cytoarchitecture and morphologically abnormal cell types, such as dysplastic neurons (DNs) and giant cells (GCs).
Michelle Maldonado, B.S., Marianna Baybis, M.A., David Newman, Dennis L Kolson, M.D., Ph.D., Wei Chen, Ph.D., Guy McKhann, II, David H Gutmann, M.D., Ph.D., Peter B Crino, M.D., Ph.D.   +7 more
doaj   +1 more source

RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo

Cells, 2020
Resistin-like molecule alpha (RELMα) and YM-1 are secreted proteins implicated in murine models of alternatively activated macrophage (AA/M2) accumulation and Th2-skewed inflammation.
Lilian Ho, Ashley Yip, Francis Lao, Fernando Botelho, Carl D. Richards   +4 more
doaj   +1 more source