Results 21 to 30 of about 35,344 (261)

Monocyte/macrophage and T-cell infiltrates in peritoneum of patients with ovarian cancer or benign pelvic disease

Journal of Translational Medicine, 2006
Background We previously showed that tumor-free peritoneum of patients with epithelial ovarian cancer (EOC) exhibited enhanced expression of several inflammatory response genes compared to peritoneum of benign disease.
Ma Qing, Mueller Peter, Bassett Roland L, Patenia Rebecca, Deavers Michael, Wang Xipeng, Wang Ena, Freedman Ralph S   +7 more
doaj   +1 more source

Age-Related Hearing Loss Is Accompanied by Chronic Inflammation in the Cochlea and the Cochlear Nucleus

Frontiers in Aging Neuroscience, 2022
Age-related hearing loss (ARHL) is a major hearing impairment characterized by pathological changes in both the peripheral and central auditory systems.
Benjamin J. Seicol, Benjamin J. Seicol, Shengyin Lin, Ruili Xie, Ruili Xie   +4 more
doaj   +1 more source

CD47 (don't eat me signal) expression levels and its relationship with clinicopathologic features in early-stage prostate carcinoma

, 2022
Background Prostate cancer is a cancer with poor host immune response and could be defined as a non-T-cell inflamed tumor. Therefore, immunotherapy treatments could not be included in the treatment of prostate cancer until recently.
Kisa, Erdem, Semiz, Hüseyin Salih, Elif Atağ, Kucuk, Ulku, Ülkü Küçük, Merve Keskinkılıç, Erdem Kısa, Aziz Karaoglu, Mehmet Emin Arayıcı, Dilara Ecem Süyün, Suyun, Dilara Ecem, Keskinkılıç, Merve, Hüseyin S. Semiz, Karaoğlu, Aziz, Arayici, MEHMET EMİN, Atag, ELİF   +15 more
core   +1 more source

Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer

Frontiers in Immunology, 2022
CD147 plays an important role in promoting tumor proliferation and inhibiting cancer cell apoptosis in the tumor microenvironment. However, the mechanisms by which CD147 is involved in tumorigenesis remains unclear. This study systematically analyzed the
Jingwei Zhang, Jingwei Zhang, Zeyu Wang, Zeyu Wang, Xun Zhang, Xun Zhang, Ziyu Dai, Ziyu Dai, Wen Zhi-Peng, Jing Yu, Yun Peng, Yun Peng, Wantao Wu, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Songshan Feng, Songshan Feng, Songshan Feng, Songshan Feng, Hao Zhang, Hao Zhang, Quan Cheng, Quan Cheng, Quan Cheng, Quan Cheng   +26 more
doaj   +1 more source

Expression of ICAM-1, TNF-α, NFκB, and MAP kinase in tubers of the tuberous sclerosis complex

Neurobiology of Disease, 2003
Individuals affected with tuberous sclerosis complex (TSC) develop cortical tubers characterized by disorganized cytoarchitecture and morphologically abnormal cell types, such as dysplastic neurons (DNs) and giant cells (GCs).
Michelle Maldonado, B.S., Marianna Baybis, M.A., David Newman, Dennis L Kolson, M.D., Ph.D., Wei Chen, Ph.D., Guy McKhann, II, David H Gutmann, M.D., Ph.D., Peter B Crino, M.D., Ph.D.   +7 more
doaj   +1 more source

Systemic Inflammation Associates With a Myeloid Inflamed Tumor Microenvironment in Primary Resected Colon Cancer—May Cold Tumors Simply Be Too Hot?

Frontiers in Immunology, 2021
Systemic inflammation measured by the acute-phase protein CRP associates with poor outcome across cancer types. In contrast, local tumor-associated inflammation, primarily evaluated by T-lymphocytes, correlates with favorable prognosis.
Anne Helene Køstner, Patricia Switten Nielsen, Jeanette Baehr Georgsen, Erik Thorlund Parner, Mette Bak Nielsen, Christian Kersten, Christian Kersten, Torben Steiniche   +7 more
doaj   +1 more source

Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas [PDF]

, 2012
BACKGROUND: Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune ...
Al-Shibli, Khalid Ibrahim, Kilvær, Thomas Karsten, Valkov, Andrey Yurjevich, Busund, Lill-Tove, Smeland, Eivind, Dønnem, Tom, Sørbye, Sveinung Wergeland, Bremnes, Roy M.   +7 more
core   +1 more source

RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo

Cells, 2020
Resistin-like molecule alpha (RELMα) and YM-1 are secreted proteins implicated in murine models of alternatively activated macrophage (AA/M2) accumulation and Th2-skewed inflammation.
Lilian Ho, Ashley Yip, Francis Lao, Fernando Botelho, Carl D. Richards   +4 more
doaj   +1 more source

Immunohistochemical evaluation of aquaporin-4 and its correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 expressions in fatal traumatic brain injury [PDF]

, 2018
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Our understanding of its pathobiology has substantially increased.
Neri, Margherita, Marco Di Paolo, Fineschi V., Raffaele La Russa, Zamparese R., Vittorio Fineschi, Cantatore S., Frati, Paola, Maiese, Aniello, Sessa F., Di Paolo, Marco, Di Paolo M., La Russa, Raffaele, Sessa, Francesco, Scopetti, Matteo, Francesco Sessa, Scopetti M., Alessandro Santurro, Matteo Scopetti, Paola Frati, Zamparese, Rosanna, Neri M., Frati P., Fineschi, Vittorio, Luigi Cipolloni, Santurro, Alessandro, Frati, Alessandro, Emanuela Turillazzi, Frati A., Cantatore, Santina, Cipolloni, Luigi, Margherita Neri, La Russa R., Turillazzi, Emanuela, Maiese A., Aniello Maiese, Santurro A., Cipolloni L., Santina Cantatore, Alessandro Frati, Turillazzi E., Rosanna Zamparese   +41 more
core   +1 more source

Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma [PDF]

, 2016
While immunotherapy may offer promising new approaches for high grade meningiomas, little is currently known of the immune landscape in meningiomas. We sought to characterize the immune microenvironment and a potentially targetable antigen mesothelin ...
Han, Seunggu J, Molinaro, Annette M, Magill, Stephen T, Kohanbash, Gary, Butowski, Nicholas A, Theodosopoulos, Philip V, Reis, Gerald, Berger, Mitchel S, Shrivastav, Shruti, McDermott, Michael W, Okada, Hideho, Aghi, Manish K, Phillips, Joanna J, Barani, Igor, Perry, Arie   +14 more
core   +1 more source