Results 1 to 10 of about 376,687 (246)

KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

Cell Reports, 2023
Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi, June-Young Koh, Min-Seok Rha, In-Ho Seo, Hoyoung Lee, Seongju Jeong, Su-Hyung Park, Eui-Cheol Shin   +7 more
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HLA-DR Expression Level in CD8+ T Cells Correlates With the Severity of Children With Acute Infectious Mononucleosis

Frontiers in Immunology, 2021
BackgroundThis study aimed to assess the host immune signatures associated with EBV infection and its clinical value in indicating the severity of children with acute infectious mononucleosis (IM).MethodsTwenty-eight pediatric patients with IM aged 3–8 ...
Yun Wang, Ying Luo, Guoxing Tang, Renren Ouyang, Minxia Zhang, Yuhuan Jiang, Ting Wang, Xiwen Zhang, Botao Yin, Jin Huang, Wei Wei, Min Huang, Feng Wang, Shiji Wu, Hongyan Hou   +14 more
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Functional Characterization of Ly49+CD8 T-Cells in Both Normal Condition and During Anti-Viral Response

Frontiers in Immunology, 2021
The role of Ly49+CD8 T-cells in the immune system is not clear. Previously, several papers suggested Ly49+CD8 T-cells as immunosuppressors, while multiple studies also suggested their role as potent participants of the immune response.
Dmytro Shytikov, Deepak Rohila, Dan Li, Pengfei Wang, Mei Jiang, Mingxu Zhang, Mingxu Zhang, Qin Xu, Linrong Lu, Linrong Lu, Linrong Lu   +10 more
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CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs. [PDF]

PLoS ONE, 2013
Protection against many intracellular pathogens is provided by CD8 T cells, which are thought to need CD4 T cell help to develop into effective memory CD8 T cells.
Pablo A Romagnoli, Mary F Premenko-Lanier, Gilbert D Loria, John D Altman   +3 more
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells

BMC Immunology, 2023
Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn, Tai-Gyu Kim   +3 more
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CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

Frontiers in Immunology, 2022
IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicated as a
Anneline C. Hinrichs, Anneline C. Hinrichs, Sofie L. M. Blokland, Sofie L. M. Blokland, Aike A. Kruize, Floris P. J. Lafeber, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +8 more
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HELIOS-expressing human CD8 T cells exhibit limited effector functions

Frontiers in Immunology, 2023
IntroductionThe transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells.
Damien Neyens, Thibault Hirsch, Achraqat Abdel Aziz Issa Abdel Hadi, Nicolas Dauguet, Christophe Vanhaver, Alexandre Bayard, Claude Wildmann, Mathieu Luyckx, Mathieu Luyckx, Jean-Luc Squifflet, Jean-Luc Squifflet, Quentin D’Hondt, Céline Duhamel, Antoine Huaux, Virginie Montiel, Mélanie Dechamps, Pierre van der Bruggen, Pierre van der Bruggen   +17 more
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Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

BMC Pulmonary Medicine, 2021
Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear.
Yingyi Wang, Na Zhou, Rui Zhu, Xiaoyuan Li, Zhao Sun, Yang Gao, Wei Liu, Changting Meng, Yuping Ge, Chunmei Bai, Taisheng Li, Hongsheng Liu   +11 more
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Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.

PLoS ONE, 2014
CD8(+) T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear.
Jang-Jaer Lee, Chiou-Yueh Yeh, Chiau-Jing Jung, Ching-Wen Chen, Mao-Kuang Du, Hui-Ming Yu, Chia-Ju Yang, Hui-Yi Lin, Andy Sun, Jenq-Yuh Ko, Shih Jung Cheng, Yen-Liang Chang, Jean-San Chia   +12 more
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Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression

Cancer Medicine, 2020
The objective of this study was to predict the value of lymphocyte subsets in cancer progression. Peripheral blood was obtained from 327 untreated patients with cancer and 158 healthy volunteers.
Ying‐Yi Wang, Na Zhou, Hong‐sheng Liu, Xiao‐Lei Gong, Rui Zhu, Xiao‐Yuan Li, Zhao Sun, Xu‐Hong Zong, Ning‐Ning Li, Chang‐Ting Meng, Chun‐Mei Bai, Tai‐Sheng Li   +11 more
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