Results 201 to 210 of about 623,857 (304)

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

CXCR5 identifies stem-like resident memory CD8⁺ T cells enriched for latent EBV specificity in tonsils. [PDF]

Sci Adv
Rivera Ballesteros O, Rieble L, Cai C, Sekine T, Nilsén V, Adamo S, Müller TR, Constantz C, Niessl J, White E, Ko Y, Kammann T, Mouchtaridi E, Gao Y, Mily A, Raineri EJM, Stamper C, Marchalot A, Wild N, Brownlie D, Llewellyn-Lacey S, Tibbitt C, Michaëlsson J, Marquardt N, Mjösberg J, Jorns C, Sandberg JK, Driving J, Price DA, Buggert M.   +29 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Targeting PIM2 improves antitumor immunity through promoting effector function and persistence of CD8 T cells. [PDF]

J Clin Invest
Wu Y, Tian L, Pugel A, Alimohammadi R, Cheng Q, Cui W, Nishimura MI, Ball LE, Lin CW, Mehrotra S, Kraft AS, Yu XZ.   +11 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin. [PDF]

Sci Adv
Migayron L, Merhi R, Avril C, Léonard S, Zouine A, Jouenne F, Gilardeau S, Drullion C, Thiolat D, Mertinaj E, Humeau M, Mauroux A, Guégan JP, Gauthereau X, Mourah S, Darde T, Bordes S, Closs-Gonthier B, Seneschal J, Boniface K.   +19 more
europepmc   +1 more source

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer. [PDF]

J Clin Invest
Napolitano F, Wang Y, Sudhan DR, Gonzalez-Ericsson PI, Formisano L, Unni N, Shakeel S, Zhu JZ, Ahuja K, Guo L, Chica-Parrado MR, Matsunaga Y, Luna P, Lin CA, Uemoto Y, Lee KM, Ma H, Evans NJ, Servetto A, Mendiratta S, Barnes SD, Bianco R, Fang YV, Xu L, Lee J, Wang T, Balko JM, Mills GB, Labrie M, Hanker AB, Arteaga CL.   +30 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells. [PDF]

Cardiovasc Res
Jorgacevic I, Shaikh H, Ali H, Bundalo M, Schäfer S, Kern MAG, Büttner-Herold M, Reu-Hofer S, Cochain C, Bartolomaeus H, Saliba AE, Rösch M, Rizzo G, Arellano Viera E, Gamboa Vargas J, Berberich-Siebelt F, Herr W, Boon L, Rosenwald A, Butt E, Hermanns HM, Beilhack A, Zernecke A.   +22 more
europepmc   +1 more source