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Current Opinion in Immunology, 1994
Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no ...
P C, Doherty, S, Hou, R A, Tripp
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Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no ...
P C, Doherty, S, Hou, R A, Tripp
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CD8+ T cells have commitment issues
Nature Immunology, 2018T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.
Renu Balyan +2 more
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American Journal of Respiratory and Critical Care Medicine, 2002
This chapter focuses on CD8 T cells, with an emphasis on the major histocompatibility complex (MHC) Ia-restricted T cells in tuberculosis, and also touches upon the unconventional CD8 T cells restricted by β2m-associated nonclassical MHC Ib or MHC I-like molecules. Although the T cells which recognize mycobacterial glycolipids in the context of group I
Vanja, Lazarevic, JoAnne, Flynn
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This chapter focuses on CD8 T cells, with an emphasis on the major histocompatibility complex (MHC) Ia-restricted T cells in tuberculosis, and also touches upon the unconventional CD8 T cells restricted by β2m-associated nonclassical MHC Ib or MHC I-like molecules. Although the T cells which recognize mycobacterial glycolipids in the context of group I
Vanja, Lazarevic, JoAnne, Flynn
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CD8+ T-cell immunity to cytomegalovirus
Human Immunology, 2004Cytomegalovirus is arguable the most immunodominant antigen that is encountered by the human immune system. CMV latency results from chronic immune suppression of viral application and the CD8(+) T cell appears to be the most important effector cell in this regard.
Paul, Moss, Naeen, Khan
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CD8+ T cells in systemic sclerosis
Immunologic Research, 2011Systemic sclerosis (SSc) is a progressive and highly debilitating autoimmune disorder characterized by inflammation, fibrosis, and vascular damage of the connective tissue. T cell-derived cytokines have been implicated in the induction of fibrosis.
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Helping the CD8+ T-cell response
Nature Reviews Immunology, 2004Cytotoxic T lymphocytes (CTLs) that express the CD8 co-receptor are the guided missiles of the immune system. They express clonally distributed receptors for foreign antigen, undergo marked proliferation in response to infection and kill any cell that expresses their target antigen.
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CD8+ T cells in atopic disease
Current Opinion in Immunology, 1998In recent years there has been a tremendous expansion in our understanding about CD8(+) T cells. We now know that, as for CD4(+) T cells, they can be divided into subsets (Tc1 and Tc2) according to the cytokines they secrete. These subsets may differ in their capacity to kill and may even, in some cases, provide help for B cell antibody production or ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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