Results 91 to 100 of about 14,873,839 (295)

Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity [PDF]

, 2011
<p><b>Background:</b> Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer).
Taracha, E. L. N., Mwangi Duncan M., Graham Simon P., Paul R. Spooner, Graham, S. P., Saya, RM, Toye, PG, Njahira, Moses N., Pelle, R., Richard P Bishop, Musoke, AJ, Silva, J., Rosemary M. Saya, Philip G Toye, Toye Philip G., Njahira, M.N., Saya, R. A., Evans L. N. Taracha, Musoke, A. J., Pelle Roger, Odongo, DO, Silva Joana C., Roger Pelle, Musoke Anthony J., Morrison, Ivan, Weir, W., Silva, J.C., Anthony J. Musoke, Joana C Silva, Graham, SP, Bishop, Richard P., Odongo, David O., Simon P Graham, Paul R Spooner, Taracha, EL, Morrison W. Ivan, Pelle, R, Bishop, R.P., Toye, P. G., Moses N Njahira, Saya Rosemary M., Duncan M. Mwangi, Spooner, P.R., Osaso Julius, Mwangi, D.M., W. Ivan Morrison, Toye, P.G., Silva, J. C., David O. Odongo, Osaso, J, Morrison, WI, Simon P. Graham, Moses N. Njahira, Mwangi, D. M., Evans L N Taracha, Taracha Evans L. N., Mwangi, DM, Odongo, D.O., Taracha, E.L.N., Bishop, RP, Morrison, W.I., Bishop, R. P., Njahira, M. N., Saya, R.M., Spooner, PR, Musoke, A.J., Saya, Rosemary M., Spooner, P. R., Richard P. Bishop, Pelle, Roger, Mwangi, David Miano, Spooner Paul R., Rosemary M Saya, Odongo David O., Njahira, MN, Joana C. Silva, Odongo, D. O., Duncan M Mwangi, Julius Osaso, W Ivan Morrison, Toye, Philip G., Njahira Moses N., Philip G. Toye, Morrison, W. Ivan, David O Odongo, Weir William, Bishop Richard P., Silva, JC, Osaso, J., Anthony J Musoke, Graham, S.P., William Weir, Weir, W   +92 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development [PDF]

, 2010
PhDThe pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes through the “β-selection ...
Mahtani-Patching, Juliet L
core   +4 more sources

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]

, 2013
CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon, T. Ueno, P. Fiorina, Baogong Zhu (399443), B. Zhu, Sayegh, Mohamed, Mohammed Javeed I. Ansari (399445), Antje Habicht (367049), A. Habicht, D'Addio, Francesca, Baogong Zhu, G. J. Freeman, Francesca D’Addio (289857), Mohammed Javeed I Ansari, Takuya Ueno (38813), Andrea Vergani (289866), Zhu, Baogong, F. D'Addio, Antje Habicht, M. H. Sayegh, Takuya Ueno, M. Clarkson, Clarkson, Michael, Habicht, Antje, D’Addio, Francesca, M. J. I. Ansari, Paolo Fiorina, Gordon J Freeman, Andrea Vergani, Mohammed Javeed, I. Ansari, Mohamed H. Sayegh (399444), Ansari, Mohammed Javeed I., Ueno, Takuya, Mohamed H Sayegh, Freeman, Gordon J., Michael Clarkson (399442), Fiorina, Paolo, Gordon J. Freeman (267166), Gordon J. Freeman, Vergani, Andrea, Mohamed H. Sayegh, Paolo Fiorina (251367), Michael Clarkson, A. Vergani, Sayegh, Mohamed H., Francesca D'Addio   +46 more
core   +2 more sources

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

CD4+CD8+ Double-Positive T-Lymphocytes: Pitfalls

Turkish Journal of Hematology, 2020
İrfan Yavaşoğlu
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source

Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes [PDF]

, 2001
Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity.
Nicholls, Philip K., Parry, N.R., Gough, Gerald W., Anderson, Davina M., Gough, G.W., Stanley, M.A., Parry, Nigel R., Stanley, Margaret A., Nicholls, P.K., Moore, Peter F., Moore, Richard A., Moore, R.A., Anderson, D.M., Moore, P.F.   +13 more
core   +1 more source