Results 71 to 80 of about 15,870,834 (185)

Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19

Open Medicine
The main objective of this study was to investigate the association between CD4+ and CD8+ lymphocyte values and disease severity, need for oxygen therapy and disease outcomes.
Jovičić Biljana Popovska, Raković Ivana, Đorđević Nemanja, Gavrilović Jagoda, Čanović Predrag, Marjanović Ružica Radojević, Petrović Sara, Milosavljević Katarina B., Divjak Ana, Stanković Nenad, Paunović Milan, Milosavljević Miloš Z.   +11 more
doaj   +1 more source

JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients

Journal of Translational Medicine, 2012
Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta, Saresella Marina, Hernis Ambra, Marventano Ivana, Ricci Cristian, Agostini Simone, Rovaris Marco, Caputo Domenico, Clerici Mario   +8 more
doaj   +1 more source

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core   +1 more source

In Reply to: CD4+CD8+ Double-Positive T-Lymphocytes: Pitfalls

Turkish Journal of Hematology, 2020
Miguel Santiago Gonzalez-Mancera, John Mario Gonzalez   +1 more
doaj   +1 more source

Stereological quantification of tumor infiltrating immune cells as predictor of immunotherapy in metastatic melanoma

Experimental and Molecular Pathology
Immunotherapy by immune checkpoint inhibitors (ICIs) revolutionized the treatment of melanoma patients. Tumor-infiltrating immune cells (TIICs) play a crucial role in antitumor immunity activated by ICIs.
Lenka Vaňková, Jiří Polívka, Věra Křížková, Samuel Vokurka, Ondřej Fiala, Monika Holubová, Kristýna Pivovarčíková, Inka Třešková, Tereza Knížková, Jan Říčař, Radek Kučera, Martin Pešta   +11 more
doaj   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source

CD101-expression sustains CD8-positive T lymphocytes and Tregs.

, 2019
Representative profiles of inflammatory infiltrates in pancreatic islets of CD101+/+ and CD101−/− NOD.B6 Idd10 mice show that they consist mainly of TCRβ+ T lymphocytes (A).
Michael E. Fusakio (6843104), Robert Opoka (3412868), Jan Clark (6843119), Heather I. Fraser (6843122), Jochen Mattner (354236), Javid P. Mohammed (6843101), Regina Schey (6843116), Marius Wrage (6843113), Daniel B. Rainbow (399462), Linda S. Wicker (5931), Carl-Philipp Hackstein (6843110), Claudia Giessler (6843107)   +11 more
core   +1 more source

The expression of programmed death 1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma and its correlation with prognosis

Zhongguo aizheng zazhi, 2021
Background and purpose: Programmed death 1 (PD-1) plays an important role in the regulation of peripheral immune tolerance. The expression of PD-1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma (HCC) and the relationship between PD-1 ...
肖　锋, 肖静文, 邵建国, 陈丽燕, 顾春燕   +4 more
doaj  

A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection [PDF]

, 1988
The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Keil, Günther M., Jonjic, Stipan   +4 more
core   +1 more source

Selective escape from CD8+ T-Cell responses represents a major driving force of Human Immunodeficiency Virus Type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [PDF]

, 2005
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear.
Rockstroh, J.K., O'Sullivan, K.M., Maier, E.L., Reyor, L., DeSouza, I., Altfeld, M., Moore, C., Lahaie, M.P., Johnston, M.N., Feeney, M.E., Rosenberg, E.S., Draenert, R., Kaufmann, D.E., Kalife, E.T., Brander, C., Eldridge, R.L., Walker, B.D., Tanzi, G., Jessen, H., Allen, T.M., Mallal, S.A., Geer, S.C.   +21 more
core