Results 51 to 60 of about 15,870,834 (185)

Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects

Biological Procedures Online, 2003
CD8+ cytotoxic T lymphocyte (CTL) activity is currently believed to be one of the key immunologic mechanisms responsible for the prevention or attenuation of HIV-1 infection.
Mahajan Supriya D., Aalinkeel Ravikumar, Schwartz Stanley A., Chawda Ram P., Nair Madhavan P.N.   +4 more
doaj   +1 more source

CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection ...
Zybleva S. V., Zyblev S. L.
doaj   +1 more source

Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome

Frontiers in Neurology, 2023
BackgroundThe expression of serine protease granzyme-B (GzmB) by circulating CD8+ T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders ...
Vinícius Oliveira Boldrini, Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Lucas Scárdua Silva, Clarissa Lin Yasuda, Clarissa Lin Yasuda, Fernando Cendes, Fernando Cendes, Alessandro Santos Farias, Alessandro Santos Farias, Alfredo Damasceno, Alfredo Damasceno   +13 more
doaj   +1 more source

Regional differences in the density of Langerhans cells, CD8-positive T lymphocytes and CD68-positive macrophages: a preliminary study using elderly donated cadavers [PDF]

Anatomy & Cell Biology, 2015
To provide a better understanding of the local immune system in the face and external genitalia, i.e., the oral floor, lower lip, palpebral conjunctiva, anus and penis, we examined the distribution and density of CD1a-positve Langerhans cells, CD8-positive suppressor T lymphocytes and CD68-positive macrophages using specimens from 8 male elderly ...
Omine, Yuya, Hinata, Nobuyuki, Yamamoto, Masahito, Kasahara, Masaaki, Matsunaga, Satoru, Murakami, Gen, Abe, Shin-ichi   +6 more
openaire   +2 more sources

Age-related decrease of miRNA-92a levels in human CD8⁺ T-cells correlates with a reduction of naïve T lymphocytes

Immunity & Ageing, 2011
MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and ageing ...
Ohyashiki Michiyo, Ohyashiki Junko H, Hirota Ayako, Kobayashi Chiaki, Ohyashiki Kazuma   +4 more
doaj   +1 more source

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core   +5 more sources

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]

, 2013
CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon, T. Ueno, P. Fiorina, Baogong Zhu (399443), B. Zhu, Sayegh, Mohamed, Mohammed Javeed I. Ansari (399445), Antje Habicht (367049), A. Habicht, D'Addio, Francesca, Baogong Zhu, G. J. Freeman, Francesca D’Addio (289857), Mohammed Javeed I Ansari, Takuya Ueno (38813), Andrea Vergani (289866), Zhu, Baogong, F. D'Addio, Antje Habicht, M. H. Sayegh, Takuya Ueno, M. Clarkson, Clarkson, Michael, Habicht, Antje, D’Addio, Francesca, M. J. I. Ansari, Paolo Fiorina, Gordon J Freeman, Andrea Vergani, Mohammed Javeed, I. Ansari, Mohamed H. Sayegh (399444), Ansari, Mohammed Javeed I., Ueno, Takuya, Mohamed H Sayegh, Freeman, Gordon J., Michael Clarkson (399442), Fiorina, Paolo, Gordon J. Freeman (267166), Gordon J. Freeman, Vergani, Andrea, Mohamed H. Sayegh, Paolo Fiorina (251367), Michael Clarkson, A. Vergani, Sayegh, Mohamed H., Francesca D'Addio, Habicht Antje, Zhu Baogong, Ueno Takuya, Sayegh Mohamed H., Freeman Gordon J., Vergani Andrea, Ansari Mohammed Javeed I., Clarkson Michael, Fiorina Paolo, D’Addio Francesca   +56 more
core   +2 more sources

The relationship between absolute counts of lymphocyte subsets and clinical features in patients with pulmonary tuberculosis

The Clinical Respiratory Journal, 2022
Background The aim of the present study is to investigate the clinical value and characteristics of peripheral blood lymphocyte subsets in patients with pulmonary tuberculosis (PTB) using flow cytometry.
Hui‐Ru An, Xue‐Juan Bai, Jian‐Qin Liang, Tao Wang, Zhong‐Yuan Wang, Yong Xue, Yin‐Ping Liu, Lan Wang, Xue‐Qiong Wu   +8 more
doaj   +1 more source

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation [PDF]

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

Human memory CD8+ T-cells exhibit an intrinsic metabolic advantage as reflected by increased mitochondrial functionality and high glycolytic potential [PDF]

, 2013
Intrinsic differences between na•ve and memory CD8+ T-cells affect both quality and quantity of cognate antigen response. Cellular immune function and metabolic pathways are closely linked.
Gubser, Patrick Marc
core   +1 more source