Results 41 to 50 of about 267,552 (285)

Prognostic Significance of Tumor-infiltrating CD8 + or CD3 + T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer

Chinese Medical Journal, 2015
Background: Altered immunoresponse is associated with tumorigenesis and cancer progression. This study assessed the levels of tumor-infiltrating CD3 + or CD8 + T lymphocytes and interleukin-2 (IL-2) protein in radically resected non-small cell lung ...
Chuntao Tian, Shixin Lu, Qingxia Fan, Weijie Zhang, Shunchang Jiao, Xiao Zhao, Zhiyong Wu, Liang Sun, Liuxing Wang   +8 more
doaj   +1 more source

Immunohistochemical Evaluation of CD3, CD4, CD8, and CD20 in Decidual and Trophoblastic Tissue Specimens of Patients with Recurrent Pregnancy Loss

Clinics and Practice, 2022
Recurrent miscarriages affect up to 5% of couples. CD3+ (T-lymphocytes), CD4+ (helper T-lymphocytes), CD8+ (cytotoxic T-lymphocytes), and CD20+ (B-lymphocytes) cells may participate in the pathophysiology of recurrent pregnancy loss (RPL).
Dimitrios Kavvadas, Sofia Karachrysafi, Pinelopi Anastasiadou, Asimoula Kavvada, Stella Fotiadou, Angeliki Papachristodoulou, Theodora Papamitsou, Antonia Sioga   +7 more
doaj   +1 more source

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells [PDF]

, 1998
We and others have recently identified a CD8 locus enhancer (E8I) that directs expression in mature CD8 single-positive thymocytes and peripheral CD8+ T cells and in extrathymically derived intestinal intraepithelial lymphocytes (IEL).
Ellmeier, Wilfried, Littman, Dan R, Losos, Kasia, Sunshine, Mary Jean   +3 more
core   +1 more source

Evaluation of the relation between T-Lymphocytes (CD4 + ve and CD8 + ve) and pemphigus vulgaris pathogenesis and severity

Indian Journal of Dermatopathology and Diagnostic Dermatology, 2019
Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease involving both the skin and mucus membranes. Infiltrating CD4+ and CD8+ T-lymphocytes may have a vital role in its pathogenesis.
Samia Mohamed El-Said Abd El-Naby, Maha Mohamed Amin, Manar Ali Hassan Ali, Mohammad A Gaballah   +3 more
doaj   +1 more source

Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome

Frontiers in Neurology, 2023
BackgroundThe expression of serine protease granzyme-B (GzmB) by circulating CD8+ T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders ...
Vinícius Oliveira Boldrini, Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Lucas Scárdua Silva, Clarissa Lin Yasuda, Clarissa Lin Yasuda, Fernando Cendes, Fernando Cendes, Alessandro Santos Farias, Alessandro Santos Farias, Alfredo Damasceno, Alfredo Damasceno   +13 more
doaj   +1 more source

High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability [PDF]

, 2008
High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes.
A Benner, A Buckowitz, AH Banham, C Lengauer, C Loddenkemper, CM Cabrera, CM Wright, CR Boland, D Nagorsen, DC Bicknell, E Sato, EM Shevach, F Ichihara, G Roncador, I Atreya, I Saeterdal, JD Fontenot, JD Fontenot, JM Michael-Robinson, K Kono, K Okada, KL Knutson, KL Ling, M Kloor, M Kloor, M Linnebacher, M Tariverdian, M von Knebel Doeberitz, M Yamamoto, MA Jenkins, N Grabe, N Wentzensen, P Findeisen, P Hoefler, R Dolcetti, R Khattri, S Hinz, S Hori, S Le Gouvello, S Michel, S Popat, SL Clarke, SM Phillips, T Pommerencke, T Sasada, TC Smyrk, U Baron, Y Naito, Y Schwitalle   +48 more
core   +2 more sources

Association of tumor-infiltrating T lymphocytes with intestinal-type gastric cancer molecular subtypes and outcome [PDF]

, 2021
While host immune response is likely to be important for the prognosis of gastric cancer patients, detailed information on the T lymphocyte infiltration in different gastric cancer subtypes is lacking. Here, we studied the presence of CD3, CD8, and FOXP3
Birkman, Eva-Maria, Carpén, Olli, Heuser, Vanina D., Lehtinen, Laura, Lintunen, Minnamaija, Mansuri, Naziha, Ristamäki, Raija, Sundström, Jari, Ålgars, Annika   +8 more
core   +1 more source

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

Clinical significance of assessing the subpopulation composition of blood lymphocytes in patients with infectious corneal lesions in high-risk keratoplasty

Российский офтальмологический журнал, 2020
The purpose is to study the shifts in the subpopulation composition of blood lymphocytes in patients with infectious corneal lesions, depending on the number of keratoplasties (KP) undergone by the patient.Material and methods.
V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, I. G. Kulikova, H. M. Shamkhalova   +4 more
doaj   +1 more source

Respiratory Syncytial Virus Infection Induces Expression of Inducible Nitric Oxide Synthase, CD3, and CD8 in Naturally Occurring Pneumonia in Lambs

Acta Veterinaria, 2021
Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj   +1 more source