Results 71 to 80 of about 267,552 (285)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

A Double-Positive CD4+CD8+ T-Cell Population Is Commonly Found in Nodular Lymphocyte Predominant Hodgkin Lymphoma [PDF]

, 2006
Aliyah Rahemtullah, Kaaren K. Reichard, Frederic I. Preffer, Nancy L. Harris, Robert P. Hasserjian   +4 more
  +4 more sources

Lymphocytes Are the Major Reservoir for Foamy Viruses in Peripheral Blood [PDF]

, 1996
Simian and human foamy virus (FV) DNA can be readily detected in peripheral blood leukocytes. However, it is unknown which leukocyte populations harbor the virusin vivo.We, therefore, analyzed blood samples from nine African green monkeys, four ...
Heeney, Jonathan Luke, Laer, Dorothee von, Neumann-Haefelin, Dieter, Schweizer, Matthias   +3 more
core   +1 more source

Dynamic causal modelling of immune heterogeneity [PDF]

arXiv, 2020
An interesting inference drawn by some Covid-19 epidemiological models is that there exists a proportion of the population who are not susceptible to infection -- even at the start of the current pandemic. This paper introduces a model of the immune response to a virus.
arxiv  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Assessment of adaptive immune responses of dairy cows with Burkholderia contaminans-induced mastitis

Frontiers in Microbiology, 2023
Burkholderia contaminans, an emerging pathogen related to cystic fibrosis, is known to cause potentially fatal infections in humans and ruminants, especially in immunocompromised individuals.
Zhipeng Zhang, Zhipeng Zhang, Yiyang Yao, Jiayu Yang, Hui Jiang, Ye Meng, Wenqiang Cao, Fuzhen Zhou, Kun Wang, Zhangping Yang, Zhangping Yang, Chunhua Yang, Jie Sun, Yi Yang, Yi Yang   +14 more
doaj   +1 more source

Comparison of NF-kB Regulation in Naive and Anergic Primary CD8+ T Lymphocytes [PDF]

, 2011
Due to the cytotoxic potential of CD8+ T cells, maintenance of CD8+ tolerance is critical. A major mechanism of peripheral tolerance in T lymphocytes is the induction of anergy, a refractory state caused by T lymphocyte activation in the absence of ...
Clavijo, Paul Esteban
core  

Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry [PDF]

, 1988
We studied the occurrence of T-cell subpopulations for patients with B-cell chronic lymphocytic leukemia. The CD8+ population was divided into CD8+ suppressor (CD8a+) and CD8+ cytotoxic (CD8b+) lymphocytes using difference in orthogonal light scattering.\
B.G.De Grooth, Bloem, C.H.H. Ten Napel, Catovsky, Chiokazzi, Deegan, Dickinson, Foa, Foa, Foa, Heurmann, Inoshita, J. Greve, Kay, Kay, Knapp, L.W.M.M. Terstappen, Lauria, Mankey, Mills, Mittelman, Nicholson, Platsoucas, Platsoucas, Rai, Sieber, Terstappen, Terstappen, Velardi, W. van Berkel, Worman   +30 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source