Results 191 to 200 of about 419,552 (297)

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

open access: yesAdvanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang   +10 more
wiley   +1 more source

Involvement of CD8+T Cells in Delayed-type Hypersensitivity Responses against Bovine Leukemia Virus (BLV) Induced in Sheep Vaccinated with Recombinant Vaccinia Virus Expressing BLV Envelope Glycoprotein [PDF]

open access: bronze, 1993
Kosuke Okada   +10 more
openalex   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan   +8 more
wiley   +1 more source

Expanded CD16<sup>+</sup>CD56<sup>+</sup>Granzyme B<sup>+</sup> NK like CD8<sup>+</sup> T cells an off target effect of bruton's tyrosine kinase inhibitors in Waldenström macroglobulinemia. [PDF]

open access: yesSci Rep
Hastak P   +16 more
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

open access: yesAdvanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang   +4 more
wiley   +1 more source

Differential sensitivity of CD8+ suppressor and cytotoxic T lymphocyte activity to bacterial monophosphoryl lipid A

open access: bronze, 1991
Fernando Esquivel‐Guadarrama   +2 more
openalex   +1 more source

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