Results 201 to 210 of about 729,582 (283)

L-Tetrahydropalmatine synergizes cytotoxic CD8⁺ T mediated antitumor and ferroptosis in gastric cancer. [PDF]

Cell Death Discov
Zhou L, Wei Y, Lin K, Lu Y.
europepmc   +1 more source

Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B [PDF]

, 2002
William G. Morice, Paul J. Kurtin, Ayalew Tefferi, Curtis A. Hanson   +3 more
openalex   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Integrated bulk and single-cell transcriptomics identifies shared and specific immune signatures in Takayasu Arteritis. [PDF]

Arthritis Res Ther
Xu K, Li T, Gao N, Zhang Y, Yang Y, Zhao H, Wang L, Zhu J, Liu J, Pan L.   +9 more
europepmc   +1 more source

CD8 cytotoxic T cells in cutaneous leishmaniasis [PDF]

, 2007
Joselín Hernández-Ruiz, Inge Becker
openalex   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non-small cell lung cancer. [PDF]

Cell Death Dis
Wang J, Liu F, Li Y, Gao J, Yang S, Tian M, Deng L, Yang Y, Gong B, Zhao C, Gong H, Xie Z, Zhou Y, Huang R, Luo Q, Jiang D, Wang X.   +16 more
europepmc   +1 more source

Virtual memory CD8 T cells expanded by helminth infection confer broad protection against bacterial infection [PDF]

, 2018
Jr‐Shiuan Lin, Katja Mohrs, Frank M. Szaba, Lawrence W. Kummer, Elizabeth A. Leadbetter, Markus Mohrs   +5 more
openalex   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

CD8⁺ T cells against extracellular pathogens: more than just a cytotoxic cell. [PDF]

Immunol Cell Biol
Silva RCMC.
europepmc   +1 more source