Results 201 to 210 of about 394,263 (244)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Ex Vivo Evaluation of CD3⁺CD8⁺ T Cell Subpopulations in Red Blood Cell Concentrates: Does Storage Time Play an Important Role? [PDF]

J Clin Med
Bal SH, Kumas LT, Cevhertas L, Yilmaz I, Hiz-Ellergezen P, Budak-Sener F, Heper Y, Oral HB.   +7 more
europepmc   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

PD-1 genetic fate mapping uncovers immune cell diversity mediating the efficacy of combined PD-1 blockade and chemotherapy. [PDF]

Oncoimmunology
Yamaguchi A, Suzuki H, Takasuga S, Tatematsu M, Fuchimukai A, Endo T, Kaya H, Morishita A, Seki S, Imai K, Ebihara T.   +10 more
europepmc   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Targeting Pim2 Improves Antitumor Immunity through Promoting Effector Function and Persistence of CD8 T cells. [PDF]

J Clin Invest
Wu Y, Tian L, Pugel A, Alimohammadi R, Cheng Q, Cui W, Nishimura MI, Ball LE, Lin CW, Mehrotra S, Kraft AS, Yu XZ.   +11 more
europepmc   +1 more source

Simultaneous detection of lymphocytes and tumor cells <i>in vivo</i> in response to STING-TLR9 immunotherapy with Raman active multiplexed gold nanostars.

Nanoscale Horiz
Kothadiya S, Cutshaw GP, Mathew AP, Zielinski C, Bardhan R.   +4 more
europepmc   +1 more source

A single-arm phase Ib study of personalized peptide-pulsed dendritic cell-based multiple target cytotoxic T lymphocyte immunotherapy in combination with toripalimab as second-line therapy in advanced non-small-cell lung cancer. [PDF]

Cancer Immunol Immunother
Zhang W, Qin J, Luo J, Xiong Y, Yang F, Li B, Shen M, Geng H, Li Z, Tian X, Li S, Li R, Wang Y, Zhang X, Ren X, Sun Q, Zhou L, Liu L.   +17 more
europepmc   +1 more source

Balancing Intrinsic and Extrinsic Factors in CD8⁺ T Cell Therapy. [PDF]

Immune Netw
Lee D, Lee Y.
europepmc   +1 more source

<i>Plasmodium</i> infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model. [PDF]

Front Mol Biosci
Huang Q, Yang D, Tao Z, Yu Z, Ding W, Tao N, Liao X, Lin H, Cheng Z, Gao S, Kang Z, Xie J, Hu W, Qin L, Chen X, Yu G.   +15 more
europepmc   +1 more source