Results 201 to 210 of about 436,454 (294)

Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+ T and CD20+ B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab. [PDF]

J Cancer
Trailin A, Červenková L, Hošek P, Pivovarčíková K, Tkadlecová M, Stránský P, Hemminki K, Fiala O.   +7 more
europepmc   +1 more source

CD8+-Lymphozyt [PDF]

, 2019
openaire   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function. [PDF]

Front Immunol
Shamriz O, Bar-On Z, Yosef O, Cohen-Daniel L, Sheer A, Reuven O, Salaymeh W, Saragovi A, Somech R, Lev A, Mor-Shaked H, Tal Y, Fattal-Valevski A, Edvardson S, Berger M.   +14 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Meta-unstable mRNAs in activated CD8⁺ T cells are defined by interlinked AU-rich elements and m⁶A mRNA methylation. [PDF]

Nat Commun
Gameiro PA, Foskolou IP, Butt YA, Martens AAM, Kuret Hodnik K, Ruiz de Los Mozos I, Zandhuis ND, Hozjan Ž, Kot VM, Faraway R, Vermeulen M, Wolkers MC, Johnson RS, Ule J.   +13 more
europepmc   +1 more source

POS0862 SPECIFIC CD4+T CELL AND CD8+T CELL SIGNATURE IN TAKAYASU ARTERITIS

Kaijin Xu, Tao Li, Li Pan
openalex   +1 more source

Egr2 deletion induced phenotypical and functional changes in CD4-CD8- double negative T cells in B6/lpr mice 2589 [PDF]

Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
openalex   +1 more source