Results 201 to 210 of about 889,074 (386)

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Nature Immunology, 2019
Brian C. Miller, Debattama R. Sen, Debattama R. Sen, Rose Al Abosy, Rose Al Abosy, K. Bi, K. Bi, Y. Virkud, M. LaFleur, Kathleen B. Yates, Kathleen B. Yates, Ana Lako, K. Felt, G. S. Naik, M. Manos, E. Gjini, J. Kuchroo, J. Kuchroo, J. Ishizuka, J. Ishizuka, J. Collier, G. Griffin, G. Griffin, G. Griffin, Seth Maleri, Seth Maleri, Dawn E Comstock, Dawn E Comstock, Sarah A. Weiss, Sarah A. Weiss, Flavian D. Brown, Arpit Panda, Arpit Panda, Margaret D. Zimmer, R. Manguso, F. Hodi, S. Rodig, S. Rodig, A. Sharpe, W. Haining, W. Haining   +40 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells [PDF]

, 1989
Joanne Kurtzberg, Waldmann Ta, MP Davey, SH Bigner, J O Moore, MS Hershfield, BF Haynes   +6 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Designing of CD8+ and CD8+-overlapped CD4+ epitope vaccine by targeting late and early proteins of human papillomavirus

Biologics: Targets & Therapy, 2018
Satyavani Kaliamurthi,1 Gurudeeban Selvaraj,1 Aman Chandra Kaushik,2 Ke-Ren Gu,1,3 Dong-Qing Wei1,2 1Centre of Interdisciplinary Science – Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology ...
Kaliamurthi S, Selvaraj G, Kaushik AC, Gu KR, Wei DQ   +4 more
doaj  

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. [PDF]

, 1994
Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to ...
Fanslow, W, Fowlkes, B, Itano, A, ROBEY, Ellen   +3 more
core  

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, EarlyView.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation

Molecular Medicine
Background It is well-established that CD8+ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes.
Chenghao Li, Zongtao Liu, Zihao Wang, Wai Yen Yim, Yajun Huang, Yuqi Chen   +5 more
doaj   +1 more source

Engagement of CD4 and CD8 accessory molecules is required for T cell maturation. [PDF]

, 1989
Fred Ramsdell, B. J. Fowlkes
openalex   +1 more source

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel, Henning De May, Lauren Anderson, Lorél Y. Medina, Ellie Kennedy, Erica Flores, John O'Rourke, Marian Olewine, Irina Lagutina, Lillian Fitzpatrick, Fred Shultz, Donna F. Kusewitt, Eric Bartee, Sarah Adams, Achraf Noureddine, Rita E. Serda   +15 more
wiley   +1 more source