Results 21 to 30 of about 883,722 (384)

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

British Journal of Cancer, 2020
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
H. Raskov, A. Orhan, J. Christensen, I. Gögenur   +3 more
semanticscholar   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy

Nature, 2019
Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang, Michael F. Green, J. E. Choi, M. Gijon, Paul D. Kennedy, Jeffrey K. Johnson, P. Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, W. Gu, Rebecca J Liu, T. Lawrence, Candice Lamb, Yuri Tanno, M. Cieslik, E. Stone, G. Georgiou, T. Chan, A. Chinnaiyan, W. Zou   +29 more
semanticscholar   +1 more source

Prognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancer

OncoImmunology, 2021
OX40 (CD134) is a co-stimulatory molecule mostly expressed on activated T lymphocytes. Previous reports have shown that OX40 can be an immuno-oncology target and a clinical biomarker for cancers of various organs.
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Toraji Amano, Takayuki Ohkuri, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Masaharu Nishimura, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita, Hiroshi Isobe   +23 more
doaj   +1 more source

Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen

OncoImmunology, 2020
Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially ...
Zoila A. Lopez-Bujanda, Matthew G. Chaimowitz, Todd D. Armstrong, Jeremy B. Foote, Leisha A. Emens, Charles G. Drake   +5 more
doaj   +1 more source

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer.

Annual Review of Immunology, 2019
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression,
Laura M. McLane, Mohamed S. Abdel-Hakeem, E. Wherry   +2 more
semanticscholar   +1 more source

Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes [PDF]

, 1987
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4 ...
Bevan, Bielefeldt Ohmann, Blue, Blue, Davignon, Fazekas de St. Groth, Goverman, Jonjić, Lanier, Lanier, MacDonald, Mackay, Pescovitz, Pescovitz, Reinherz, Reinherz, Saalmüller, Scollay, Swain, Tumbleson   +19 more
core   +3 more sources

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice [PDF]

, 2012
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts.
Alice J.A.M. Sijts, Alwan, Andrea Gröne, Andrew J. Easton, Bossert, Braciale, Buchholz, Cannon, Castilow, Chang, Chen, Chin, Claassen, Claassen, Claire J.P. Boog, Cornelis P.J. Bekker, David J. Topham, Dietmar M.W. Zaiss, Dirk H. Busch, Easton, Falsey, Fenton, Frey, Fulginiti, Garvey, Graham, Hall, Heinze, Henderson, Hussell, Kapikian, Kim, Kruijsen, Kulkarni, Lo, Mary J.G. van Helden, Ostler, Ostler, Percopo, Peter J.S. van Kooten, Piedra, Polakos, Rosenberg, Rosenberg, Sherman, Srikiatkhachorn, Stevens, Stevens, Thompson, Tregoning, Varga, Zaiss   +51 more
core   +1 more source

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo [PDF]

The Journal of Experimental Medicine, 2000
Bone marrow–derived antigen-presenting cells (APCs) take up cell-associated antigens and present them in the context of major histocompatibility complex (MHC) class I molecules to CD8+ T cells in a process referred to as cross-priming. Cross-priming is essential for the induction of CD8+ T cell responses directed towards antigens not expressed in ...
den Haan, J M, Lehar, S M, Bevan, M J
openaire   +4 more sources

Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer

Endocrine Connections, 2020
Programmed cell death-ligand 1 (PD-L1) has recently been shown to play a role in the regulation of epithelial-to-mesenchymal transition (EMT); however, the relationship between PD-L1 expression, EMT and the inflammatory tumour microenvironment has yet to
Marra Jai Aghajani, Tao Yang, Ulf Schmitz, Alexander James, Charles Eugenio McCafferty, Paul de Souza, Navin Niles, Tara L Roberts   +7 more
doaj   +1 more source