Results 211 to 220 of about 93,479 (280)

A new perspective on cancer treatment: the interaction and application prospect between ICIs and radiotherapy

Precision Radiation Oncology, EarlyView.
The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song, Lei Wang, Guopeng Zhao, Song Tan, Xin Liu, Xinghua Li   +5 more
wiley   +1 more source

Chemoradiation of glioblastoma cells alters expression of activation and immune checkpoint molecules on type 1 and 2 dendritic cells and impacts on subsequent T cell proliferation. [PDF]

Clin Transl Radiat Oncol
Schuster C, Frey B, Fietkau R, Corradini S, Gaipl US, Derer A.   +5 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Cutaneous diffuse large B-cell lymphoma induces a macrophage immunosuppressive phenotype through IL-10 secretion. [PDF]

Blood Adv
Galtier J, Peanne R, Le Morvan V, Blondy T, Melane M, Bidon A, Chopin A, Prochazkova-Carlotti M, Poglio S, Merlio JP, Chevret E, Gros A, Pham-Ledard A, Beylot-Barry M, Bresson-Bepoldin L.   +14 more
europepmc   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

T‐Cell Immunity and Lung Cancer

Respirology, EarlyView.
ABSTRACT Lung cancer remains a leading cause of cancer mortality worldwide. Although immune checkpoint inhibitors (ICIs) have reshaped therapeutic strategies in lung cancer, their benefits remain limited. ICIs exert their therapeutic efficacy by activating T‐cell effector functions, underscoring the central role of T cells in antitumor immunity.
Kotaro Yamada, Yosuke Togashi
wiley   +1 more source

Abatacept today, TMA away: protecting the endothelium. [PDF]

Blood Adv
Ngwube A, Abraham A.
europepmc   +1 more source

A Multifunctional Bioactive Nanoscale Coating Deposited by Atmospheric Pressure Plasma Polymerization of Peppermint Essential Oil

Small, EarlyView.
Atmospheric plasma polymerization transforms peppermint essential oil into ultrathin, substrate‐independent bioactive coatings with antioxidant, contact‐active antibacterial, and immunomodulatory functions. The coating disrupts Gram‐negative pathogens, potentiates prophylactic antibiotics, suppresses pro‐inflammatory signaling, and promotes M2 ...
Trong Quan Luu, Xuan Duy Do, Tuyet Pham, Ngoc Huu Nguyen, Richard Bright, Wenshao Li, Xiangyang Guo, Vi Khanh Truong, Andrew Hayles, Krasimir Vasilev   +9 more
wiley   +1 more source

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. [PDF]

ACS Omega
Calvo-Barreiro L, Nada H, Upadhyay S, Gabr MT.   +3 more
europepmc   +1 more source

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

VIEW, EarlyView.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng, Tengfei Ke, Hongjin Wang, Hong Huang, Ying Zhang, Guanghai Fei, Chengde Liao, Haiyan Yang   +7 more
wiley   +1 more source