Results 201 to 210 of about 71,028 (295)

Engineered immunostimulatory H2O2‐producing microreactors driven by yeast as localized living cancer therapeutics

BMEMat, EarlyView.
Engineered yeast microreactors that produce H2O2 within tumors enable selective cancer cell killing while releasing immunostimulatory components, effectively suppressing local tumor growth and activating systemic antitumor immunity, with further efficacy enhanced by anti‐PD‐1 therapy and transarterial embolization.
Wenqian He, Chunjie Wang, Minming Chen, Weihao Yang, Bin Yu, Yuhang Hu, Hengze Ding, Yifan Yan, Zhijuan Yang, Liangzhu Feng   +9 more
wiley   +1 more source

Targeting IFN-I driven tertiary lymphoid structures halts B cell-mediated bone loss in periodontitis. [PDF]

Int J Oral Sci
Lu J, Wu X, Xiong Z, Zhang J, Yang H, Liu F, Luo L.   +6 more
europepmc   +1 more source

Efficacy and Safety of Durvalumab and Tremelimumab in Metastatic Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA 2020 flow diagram of included studies. ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low ...
Ikhwan Rinaldi, Eric Ricardo Yonatan, Tasia Esterita   +2 more
wiley   +1 more source

Feline-Derived <i>Lactiplantibacillus plantarum</i>-Aloe Vera Polysaccharide Hydrogel as a Topical Control Strategy for <i>Staphylococcus pseudintermedius</i>-Infected Wounds. [PDF]

Vet Sci
Chen Q, Dong H, Wang W, Wang H, Yao J, Ma M, Zhu S, Zhu L, Du Z, Xia Z, Xiong W.   +10 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

IRAK-M Knockout Exacerbates Inflammation in Mice Infected with <i>Streptococcus equi</i> subsp. <i>zooepidemicus</i>: Observation in the Jejunum. [PDF]

Microorganisms
Che Y, Xie Y, Qiu X, Lin J, Xiu Y, Yu T, Zhan X, Liao J, Huang Y, Ye Y, Deng Z.   +10 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Co-stimulatory signal deficiency impairs cytotoxic T lymphocyte function in tumor immune evasion: molecular mechanisms and therapeutic implications. [PDF]

J Transl Med
Ma J, Chen J, Miao T, Li Y, Li Y, Zhao L, Tian H.   +6 more
europepmc   +1 more source