Results 231 to 240 of about 69,003 (290)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Synergistic nanoparticle dyad improving tumor immunogenicity and reshaping tolerogenic dendritic cells in hepatocellular carcinoma. [PDF]

Mater Today Bio
Liu C, Zhao X, Song H, Yuan Y, Ma J, Dong Y, Xu T, Li X, Liu X.   +8 more
europepmc   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

[Isolation, purification and immunomodulatory activity of polysaccharide from <i>Lonicera caerulea</i> L. var. <i>edulis</i> Turcz. ex Herder]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Huang Y, Zhang X, Xiang Q, Guo H, Zheng S, Hao Y, Liao W.   +6 more
europepmc   +1 more source

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells. [PDF]

Front Immunol
Lindenbergh PL, Rajasekhar VK, Linkov I, Mansilla-Soto J, Hanina SA, Sadelain M.   +5 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Oridonin Ameliorates Concanavalin A-Elicited Hepatitis in Mice: Insight into Suppressing TLR7/PKM2/NLRP3-Driven Inflammation and M1/M2 Polarization. [PDF]

J Xenobiot
Dhahir S, Amin FM, Nader MA.
europepmc   +1 more source

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

National Materials, EarlyView.
In this study, we engineered an antibacterial, antioxidative and epidermal grow factor‐encapsulated multifunctional hydrogel for the repair of chronic and refractory wounds. The hydrogel markedly promoted wound healing in rat models of diabetic foot ulcers and infected wounds by modulating wound microenvironment.
Zheng Zou, Yang Gao, Desheng Qi, Zhen Zhang, Chaoliang He, Xuesi Chen   +5 more
wiley   +1 more source

Promoting APC function of B cells via reprogramming the fatty acid metabolism enhances anticancer immunity in metastatic ovarian cancer. [PDF]

Cancer Immunol Immunother
Zhang H, Yu C, Du W, Li H, Liu Z, Li X, Yue Y, Wang B, Wang H, Ouyang Y, Wu H, Feng X, Yu J, Liu Y, Ji B, Cai S, Zhang H, Deng W.   +17 more
europepmc   +1 more source

Adalimumab Reprograms M1 Macrophages to Attenuate Th1/Th17 Responses in Behçet's Uveitis and Vogt-Koyanagi-Harada Syndrome. [PDF]

Invest Ophthalmol Vis Sci
Zhu Y, Yu Q, Ma Y, Huang L, Ding J, Gao X, Ma L, Zhang D, Zhang B, Wang S, Chu WK, Su G, Yang P.   +12 more
europepmc   +1 more source