Results 241 to 250 of about 71,028 (295)

Perithyroidal Adipose Tissue Drives Thyroid Tumorigenesis through Adipokine Signaling and Immune Suppression. [PDF]

Research (Wash D C)
Long Q, Zhang Z, Lin B, Yu Z, Xu M, Zhao ST, Li J, Gu P, Xie M, Zhao X, Deng T, Yang W, Cheng AS, Yang W, Lv W, Pan Y, Hui HX.   +16 more
europepmc   +1 more source

TGF-β-PDL1 signaling in neutrophils preserves the lung barrier during hyperinflammation.

Blood
Li Z, Moore AR, Zheng H, Karunamurthy J, Bhagrath A, Li J, Young D, Jurado LF, Couto K, Kulle A, Park H, Kwak A, Belur V, Talbot S, Divangahi M, DiGiandomenico A, Rogers A, Cohen TS, Ehrlicher AJ, Mandl JN, Wang J, Dufour A, Khatri P, Thanabalasuriar A.   +23 more
europepmc   +1 more source

Signaling Through CD80: An Approach for Treating Lymphomas

Expert Opinion on Therapeutic Targets, 2008
Background: One of the mechanisms by which tumors evade the immune system is by downregulating the expression of costimulatory molecules like CD80 and CD86.
Javed N Agrewala, Manzoor Ahmad Mir
exaly   +4 more sources

Identification of Another Primordial CD80/86 Molecule in Rainbow Trout: Insights Into the Origin and Evolution of CD80 and CD86 in Vertebrates

Developmental and Comparative Immunology, 2018
In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other ...
Yong-An Zhang, Xu-Jie Zhang, Xiang-Yang Zhang   +2 more
exaly   +2 more sources

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Tumour vaccines expressing IL-2, CD80, and IL-2 plus CD80 gene

International Journal of Oncology, 1997
Experiments were designed to investigate immunogenicity and therapeutic efficacy of tumour vaccines constructed by transfection of poorly immunogenic murine sarcoma Mc12 with synergistic CD80 and IL-2 genes. Immunization/challenge experiments demonstrated that both, IL-2(+) and IL-2(+) plus CD80(+) live cell vaccines can exert an immunizing stimulus ...
J, Bubenik, P, Rossner, D, Bubenikova, J, Simova, M, Indrova, E, Sloncova   +5 more
openaire   +2 more sources

Two Regions in the CD80 Cytoplasmic Tail Regulate CD80 Redistribution and T Cell Costimulation

The Journal of Immunology, 1998
Abstract CD28 is a major T cell costimulatory molecule, delivering signals distinct from those of the CD3/TCR complex, which regulate cytokine and cytokine receptor expression, cell proliferation, and cell viability. CD28 needs to be cross-linked to initiate signals, yet both of its ligands, CD80 and CD86, are expressed as monomers ...
R T, Doty, E A, Clark
openaire   +2 more sources

CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles

Human Immunology, 2012
CD80 and CD86 are closely linked genes on chromosome 3 that code for glycoproteins of the immunoglobulin superfamily, expressed on the surface of antigen-presenting cells. These costimulatory molecules play essential roles for stimulation and inhibition of T cells through binding to CD28 and CTLA-4 receptors.
Márcia Holsbach, Beltrame, Márcia Regina, Pincerati, Ricardo, Dalla-Costa, Roseli, Wassem, Karen Francine, Köhler, Eleidi Alice, Chautard-Freire-Maia, Luiza Tamie, Tsuneto, Maria Luiza, Petzl-Erler   +7 more
openaire   +2 more sources

Expression of CD80 promoter in transgenic mice

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2000
CD80 is a very potent co-stimulatory factor which is required for complete T-cell activation. Here, we use transgenic mice as a tool to map the promoter of the CD80 gene. We engineered three different CD80 promoter driven luciferase transgenes: -3084, -1073 and -215. With these transgenes, we have generated three groups of transgenic mice.
H, Zhang, D, Haasch, B, Patterson, B, Dickinson, G F, Okasinski   +4 more
openaire   +2 more sources