Results 241 to 250 of about 69,003 (290)

<i>Laggera alata</i> attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization. [PDF]

Mol Med Rep
Wei J, Zhong W, Zhou G, Huang M, Huang X, Liang J.   +5 more
europepmc   +1 more source

CD80⁺ Macrophage-Induced IL-17⁺CD8⁺ T cells accumulate in hyperlipidemic patients and murine vascular lesions to promote atherosclerotic progression. [PDF]

Cell Commun Signal
Wang Y, Li P, Li W, Zou Y, Zhao Y, Ma L, Zhao T, Chai X, Liu S, Yuan Z, Hassan M, Wang T, Yu C.   +12 more
europepmc   +1 more source

3M-052 combined inhibitory anti-TNFR2 synergistically suppresses colon cancer progression. [PDF]

Front Immunol
Jing Q, Luo J, Wan Q, Jing Q, Hu X, Nei C, Zhang X, Zhou Y, Tang J, Wang Y, Ding Y, Nie Y, Li W, Nie Y.   +13 more
europepmc   +1 more source

Radiotherapy-synergized in situ hydrogel vaccine with engineered <i>Lactococcus lactis</i> FOLactis potentiates anti-tumor immunity in pancreatic cancer. [PDF]

Front Immunol
Chen J, Wang Q, Zhu J, Bai X, Tang H, Kong X, Zou L, Zheng Q, Wang Y, Zhao Y, Liu B, Meng F, Du J.   +12 more
europepmc   +1 more source

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Tumour vaccines expressing IL-2, CD80, and IL-2 plus CD80 gene

International Journal of Oncology, 1997
Experiments were designed to investigate immunogenicity and therapeutic efficacy of tumour vaccines constructed by transfection of poorly immunogenic murine sarcoma Mc12 with synergistic CD80 and IL-2 genes. Immunization/challenge experiments demonstrated that both, IL-2(+) and IL-2(+) plus CD80(+) live cell vaccines can exert an immunizing stimulus ...
J, Bubenik, P, Rossner, D, Bubenikova, J, Simova, M, Indrova, E, Sloncova   +5 more
openaire   +2 more sources

Two Regions in the CD80 Cytoplasmic Tail Regulate CD80 Redistribution and T Cell Costimulation

The Journal of Immunology, 1998
Abstract CD28 is a major T cell costimulatory molecule, delivering signals distinct from those of the CD3/TCR complex, which regulate cytokine and cytokine receptor expression, cell proliferation, and cell viability. CD28 needs to be cross-linked to initiate signals, yet both of its ligands, CD80 and CD86, are expressed as monomers ...
R T, Doty, E A, Clark
openaire   +2 more sources

Expression of CD80 promoter in transgenic mice

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2000
CD80 is a very potent co-stimulatory factor which is required for complete T-cell activation. Here, we use transgenic mice as a tool to map the promoter of the CD80 gene. We engineered three different CD80 promoter driven luciferase transgenes: -3084, -1073 and -215. With these transgenes, we have generated three groups of transgenic mice.
H, Zhang, D, Haasch, B, Patterson, B, Dickinson, G F, Okasinski   +4 more
openaire   +2 more sources

Interactions of CD80 and CD86 with CD28 and CTLA4

The Journal of Immunology, 1996
Abstract CD80 and CD86 are cell surface glycoproteins expressed on a variety of professional APCs. They have attracted much attention due to their function as potent costimulators of T lymphocyte function through their interaction with CD28 and possibly CTLA4. Because inhibitors of this interaction may have therapeutic relevance in human
J H, Ellis, M N, Burden, D V, Vinogradov, C, Linge, J S, Crowe   +4 more
openaire   +2 more sources

Regulation of self-tolerance by CD80/CD86 interactions

Current Opinion in Immunology, 1997
Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from ...
P, Lu, Y L, Wang, P S, Linsley
openaire   +2 more sources

CD80 Expression on Monocytes in HIV-Infected Patients

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1997
A prominent feature of HIV infection is a progressive anergy of T cells and an increase of activation-dependent T-cell death. CD80 (B7.1), the ligand of CD28, is an important co-stimulatory molecule on antigen-presenting cells that delivers an essential second signal for T-cell activation. To test whether immunologic dysfunction in HIV disease involves
P, Löw, C, Weber, E, Harrer, P, Rohwer, J R, Kalden, T, Harrer   +5 more
openaire   +2 more sources