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Interactions of CD80 and CD86 with CD28 and CTLA4
The Journal of Immunology, 1996Abstract CD80 and CD86 are cell surface glycoproteins expressed on a variety of professional APCs. They have attracted much attention due to their function as potent costimulators of T lymphocyte function through their interaction with CD28 and possibly CTLA4. Because inhibitors of this interaction may have therapeutic relevance in human
J H, Ellis +4 more
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2016
CD80/CD86 inhibitors are protein constructs which bind and inactivate CD80/CD86 on the surfaces of antigen-presenting B-cells and monocytes, blocking the costimulatory signal between these cells and CD28 on T-cells that is the second message of T-cell receptor/MHC interaction.
Pile, Kevin (R17082) +2 more
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CD80/CD86 inhibitors are protein constructs which bind and inactivate CD80/CD86 on the surfaces of antigen-presenting B-cells and monocytes, blocking the costimulatory signal between these cells and CD28 on T-cells that is the second message of T-cell receptor/MHC interaction.
Pile, Kevin (R17082) +2 more
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Regulation of self-tolerance by CD80/CD86 interactions
Current Opinion in Immunology, 1997Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from ...
P, Lu, Y L, Wang, P S, Linsley
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CD80 Expression on Monocytes in HIV-Infected Patients
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1997A prominent feature of HIV infection is a progressive anergy of T cells and an increase of activation-dependent T-cell death. CD80 (B7.1), the ligand of CD28, is an important co-stimulatory molecule on antigen-presenting cells that delivers an essential second signal for T-cell activation. To test whether immunologic dysfunction in HIV disease involves
P, Löw +5 more
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CD80 Dimerization with PD-L1 in Cis Disrupts CTLA4–CD80 Interactions
Cancer Discovery, 2020Abstract PD-L1 can repress the CTLA4 axis to stimulate an immune response.
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013
To prepare CD80-scFv in CHO cells and investigate its effect on the recognition and proliferation of different tumor cells.The CD80-scFv was purified from culture supernatant without fetal calf serum (FCS) by IMAC affinity chromatography, and then bound to CD80 molecule on the Daudi, U251, A375 and 8266 cells detected by flow cytometry.
Li-jun, Shen +7 more
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To prepare CD80-scFv in CHO cells and investigate its effect on the recognition and proliferation of different tumor cells.The CD80-scFv was purified from culture supernatant without fetal calf serum (FCS) by IMAC affinity chromatography, and then bound to CD80 molecule on the Daudi, U251, A375 and 8266 cells detected by flow cytometry.
Li-jun, Shen +7 more
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Blockade of Trans PD-L1 Interaction With CD80 Augments Antitumor Immunity
Proceedings of the National Academy of Sciences of the United States of America, 2023Dustin E Schones +2 more
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