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Signaling through CD80: an approach for treating lymphomas
Expert Opinion on Therapeutic Targets, 2008One of the mechanisms by which tumors evade the immune system is by downregulating the expression of costimulatory molecules like CD80 and CD86. The role of CD80 in the activation of T cells is well established, and current studies are exploring its role in cancer.To examine the possible role of CD80 signaling in generating an effective immune response
Manzoor A, Mir, Javed N, Agrewala
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Terapias células T alvo (anti-CD80/86)
Revista Paulista de Reumatologia, 2021Os inibidores de CD80/86 são moléculas concebidas com o intuito de inativar os receptores CD80/86 nas superfícies de células apresentadoras de antígeno, linfócitos B e monócitos, impedindo a ligação ao CD28 localizado nas células T, bloqueando o segundo sinal coestimulatório necessário para a ativação linfocitária.
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Regulation of self-tolerance by CD80/CD86 interactions
Current Opinion in Immunology, 1997Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from ...
P, Lu, Y L, Wang, P S, Linsley
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CD28/CTLA-4 and CD80/CD86 families
Immunologic Research, 1999T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of which can prevent anergy and cell death. The CD28 receptor is a member of a complex family of polypeptides that includes at least two receptors and two ligands ...
J M, Slavik +2 more
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What's the difference between CD80 and CD86?
Trends in Immunology, 2003CD28 and CD152 have crucial yet opposing functions in T-cell stimulation, in which CD28 promotes but CD152 inhibits T-cell responses. Intriguingly, they share two ligands, CD80 and CD86, but at present there is no clear model for understanding whether a ligand will promote or inhibit responses. Current perceptions are based around the concept that CD86
David M, Sansom +2 more
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Co-stimulatory Molecule CD80 (B7.1) in MCNS
2016Minimal change nephrotic syndrome (MCNS) is the most common cause of nephrotic syndrome in children and accounts for 10–25 % of nephrotic syndrome in adults. The etiology has been postulated as T lymphocytes (T cell) disorder; however, precise mechanisms still remain unknown.
Michiko Shimada +2 more
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013
To prepare CD80-scFv in CHO cells and investigate its effect on the recognition and proliferation of different tumor cells.The CD80-scFv was purified from culture supernatant without fetal calf serum (FCS) by IMAC affinity chromatography, and then bound to CD80 molecule on the Daudi, U251, A375 and 8266 cells detected by flow cytometry.
Li-jun, Shen +7 more
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To prepare CD80-scFv in CHO cells and investigate its effect on the recognition and proliferation of different tumor cells.The CD80-scFv was purified from culture supernatant without fetal calf serum (FCS) by IMAC affinity chromatography, and then bound to CD80 molecule on the Daudi, U251, A375 and 8266 cells detected by flow cytometry.
Li-jun, Shen +7 more
openaire +1 more source