Results 91 to 100 of about 25,955 (200)

Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by Soluble CD83 [PDF]

The Journal of Experimental Medicine, 2004
CD83 is up-regulated on the surface of dendritic cells (DCs) during maturation and has been widely used as a marker for mature DCs. Recently, we reported the recombinant expression of the extracellular immunoglobulin domain of human CD83 (hCD83ext). Using this soluble form of CD83, allogeneic as well as specific cytotoxic T lymphocyte proliferation ...
Zinser, Elisabeth, Lechmann, Matthias, Golka, Antje, Lutz, Manfred B., Steinkasserer, Alexander   +4 more
openaire   +2 more sources

SUBTYPE CHARACTERICS OF DENDRITIC CELLS FROM PERIPHERAL BLOOD OF PATIENTS WITH RHEUMATOID ARTHRITIS

Медицинская иммунология, 2014
. Characteristics of myeloid and plasmacytoid dendritic cells from peripheral blood were studied in healthy donors and patients with rheumatoid arthritis (RA).
S. A. Falaleeva, V. V. Kurilin, N. S. Shkaruba, O. A. Chumasova, A. E. Sizikov, S. V. Sennikov   +5 more
doaj   +1 more source

Impact of Leishmania donovani infection on the HLA I self peptide repertoire of human macrophages [PDF]

, 2018
Macrophages are specialized antigen-presenting cells that process and present self-antigens for induction of tolerance, and foreign antigens to initiate T cell-mediated immunity.
Jarmalavicius, Saulius, Nyambura, Lydon Wainaina, Walden, Peter   +2 more
core   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, Volume 7, Issue 2, March 2026.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help [PDF]

, 2017
Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial.
Allen, Bannard, Bonifaz, Boscardin, Calado, Chambers, Chie Kawai, Dansen, De Silva, Dominguez-Sola, Dominguez-Sola, Dorsey, Draghi, Dubrovska, Gitlin, Gitlin, Gong, Hedrick, Huang, Inoue, Ise, Itano, Kitamura, Kurosaki, Kuwahara, Liu, Murphy, Murphy, Paik, Pape, Rickert, Ryo Shinnakasu, Safford, Sagardoy, Sander, Schwickert, Shih, Shinnakasu, Shlomchik, Subramanian, Takeshi Egawa, Takeshi Inoue, Taylor, Toellner, Tomohiro Kurosaki, Trinh, Victora, Victora, Victora, Victora, Wataru Ise, Zhang, Zheng   +52 more
core   +2 more sources

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

In vitro and in vivo studies of the immunomodulatory effect of Echinacea purpurea on dendritic cells

Journal of Genetic Engineering and Biotechnology, 2015
Background: Extracts of Echinacea have been used traditionally for the treatment of diverse types of infections and wounds. They have become very familiar immunostimulant herbal medicine. However, the specific immunomodulatory effect of Echinacea remains
N.E. El-Ashmawy, E.A. El-Zamarany, M.L. Salem, H.A. El-Bahrawy, G.M. Al-Ashmawy   +4 more
doaj   +1 more source

Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma [PDF]

, 2006
Background Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the absence of standard methods for DC ...
Allred Jacob B, Bulur Peggy A, Padley Douglas J, Butler Greg W, Maas Mary L, Greiner Carl W, Dietz Allan B, Markovic Svetomir N, Creagan Edward T, Ingle James N, Gastineau Dennis A, Vuk-Pavlovic Stanimir   +11 more
core   +1 more source

Staphylococcus aureus Sb‐1 Bacteriophage Alters Frequency and Subset Distribution of Human Innate Lymphoid Cells

Allergy, EarlyView.
Ramazan Rozumbetov, Ismail Ogulur, Anja Heider, Anna Globinska, Nina Chanishvili, Elene Kakabadze, Marina Goderdzishvili, Nino Grdzelishvili, Nata Bakuradze, Moelong Yu, Tamara Aripova, Adolat Ismailova, Nikolaos Papadopoulos, Mubeccel Akdis, Cezmi A. Akdis   +14 more
wiley   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source