Results 71 to 80 of about 448,583 (189)

Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome

, 2007
Mature dendritic cells (DCs) are the most potent antigen-presenting cells within the human immune system. However, Herpes simplex virus type 1 (HSV-1) is able to interfere with DC biology and to establish latency in infected individuals.
Roger D. Everett, Mirko Kummer, Kummer, M., Coffin, R.S., Nadine M. Turza, Chris Boutell, Petra Muhl-Zurbes, Alexander T. Prechtel, Steinkasserer, A., Turza, N.M., Muhl-Zurbes, P., Matthias Lechmann, Robert S. Coffin, Lechmann, M., Everett, R.D., Prechtel, A.T., Boutell, C., Alexander Steinkasserer   +17 more
core   +1 more source

Inflammatory cell expression of Toll-like receptor-2 (TLR2) within refractory periapical granuloma. [version 1; referees: 2 approved]

F1000Research, 2018
Background: Toll-like receptor-2 (TLR2) is highly important within the immune system. Characterization of the expression of TLR2 within inflammatory cells in periapical lesions could help in diagnosis and management of refractory cases.
Eric Chen, Mahmoud M. Bakr, Norman Firth, Robert M. Love   +3 more
doaj   +1 more source

Human CD83 Targeted Chimeric Antigen Receptor T Cell for the Prevention of Graft Versus Host Disease and Treatment of Myeloid Leukemia

Blood, 2019
Distinct from pharmacologic immunosuppression, we designed a programmed cytolytic effector T cell that prevents graft versus host disease (GVHD). CD83 is expressed on allo-activated conventional T cells (Tconv) and pro-inflammatory dendritic cells (DCs), which are implicated in GVHD pathogenesis.
Marco L. Davila, Brian C. Betts, Claudio Anasetti, Bruce R. Blazar, Joseph Pidala, Tayyeb Ghafoor, Justin C. Boucher, Nhan Tu, Elizabeth M. Sagatys, Jordan Reff, Kelly Walton, Bishwas Shrestha   +11 more
openaire   +1 more source

Neutrophils in Atlantic salmon (Salmo salar L.) are MHC class II+ and secret IL-12p40 upon bacterial exposure

Aquaculture and Fisheries
Antigen-presentation via major histocompatibility complex (MHC) to T cells is the key event to initiate adaptive immune responses. In teleosts, as in mammals, the main types of professional antigen-presenting cells (APCs) are dendritic cells (DCs ...
Gyri Teien Haugland, Anita Rønneseth, Lene Gundersen, Harald Sæbø Lunde, Kaja Nordland, Heidrun Inger Wergeland   +5 more
doaj   +1 more source

Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis

Hematology
Objectives To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets.Methods The optimal exosome dosage (20 µg/ml) for DC treatment was determined via ...
Jinglong Lv, Yang Tao, Hui Zhong, Xiaohong Xie, Hongxia Chen, Zhudan Hou, Wenfang Luo, Yangjun Liu, Rui Huang   +8 more
doaj   +1 more source

Efficient Maturation and Cytokine Production of Neonatal DCs Requires Combined Proinflammatory Signals

Clinical and Developmental Immunology, 2005
Specific functional properties of dendritic cells (DCs) have been suspected as being responsible for the impaired specific immune responses observed in human neonates.
Doreen Krumbiegel, Jan Rohr, Peter Schmidtke, Markus Knuf, Fred Zepp, Claudius U. Meyer   +5 more
doaj   +1 more source

Oncolytic Virus‐Engineered Extracellular Vesicles Rewire Glioblastoma Immunity

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Immunotherapy with oncolytic Herpes simplex virus type 1 (oHSV‐1) shows promise for glioblastoma; however, clinical benefit remains uncommon due to tumour‐ and host‐mediated immunosuppression, which limits immune targeting of residual glioblastoma stem‐like cells (GSCs). To address this barrier, extracellular vesicles (EVs) harvested from oHSV‐
Klaudia Kiel, Arpita Balakrishnan, Aleksandra Cabaj, Luiza Stanaszek, Maciej Przybylski, Dawid Stępnik, Marta Małuszek, Christopher Jannotta, Chiara Zoe Linke, Joanna Suszyńska‐Zajczyk, Monika Knaur, Agnieszka Szczypiorowska, Szymon Hryhorowicz, Bianka Świderska, Katarzyna Piwocka, Alexander Lee Ling, E. Antonio Chiocca, Agnieszka Bronisz, Jakub Godlewski   +18 more
wiley   +1 more source

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, Volume 270, Issue 2, Page 211-225, October 2026.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

Regulation des Zelloberflächenmoleküls CD83 durch das Epstein-Barr Virus und Analyse seiner Funktion [PDF]

, 2002
EBV is a γ-herpes virus which is able to infect human resting B-cells and to transform them into permanently growing lymphoblastoid cell lines (LCLs).
Dudziak, Diana
core   +1 more source

Expression of chicken DEC205 reflects the unique structure and function of the avian immune system.

PLoS ONE, 2013
The generation of appropriate adaptive immune responses relies critically on dendritic cells, about which relatively little is known in chickens, a vital livestock species, in comparison with man and mouse. We cloned and sequenced chicken DEC205 cDNA and
Karen Staines, John R Young, Colin Butter   +2 more
doaj   +1 more source