Results 81 to 90 of about 15,671 (193)

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Human CD83 Targeted Chimeric Antigen Receptor T Cell for the Prevention of Graft Versus Host Disease and Treatment of Myeloid Leukemia

Blood, 2019
Distinct from pharmacologic immunosuppression, we designed a programmed cytolytic effector T cell that prevents graft versus host disease (GVHD). CD83 is expressed on allo-activated conventional T cells (Tconv) and pro-inflammatory dendritic cells (DCs), which are implicated in GVHD pathogenesis.
Marco L. Davila, Brian C. Betts, Claudio Anasetti, Bruce R. Blazar, Joseph Pidala, Tayyeb Ghafoor, Justin C. Boucher, Nhan Tu, Elizabeth M. Sagatys, Jordan Reff, Kelly Walton, Bishwas Shrestha   +11 more
openaire   +1 more source

Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis

Hematology
Objectives To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets.Methods The optimal exosome dosage (20 µg/ml) for DC treatment was determined via ...
Jinglong Lv, Yang Tao, Hui Zhong, Xiaohong Xie, Hongxia Chen, Zhudan Hou, Wenfang Luo, Yangjun Liu, Rui Huang   +8 more
doaj   +1 more source

Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review

Journal of Diabetes, Volume 18, Issue 7, July 2026.
Clonal hematopoiesis (CH), driven by obesity‐ and aging‐related inflammation, may be causally associated with an increased risk of Type 2 diabetes through the inflammation–insulin resistance pathway. By exacerbating systemic inflammation, CH may also contribute to the development of macrovascular and microvascular complications in patients with Type 2 ...
Jian‐Jun Liu, Sylvia Liu, Resham L. Gurung, Su Chi Lim, Rajkumar Dorajoo   +4 more
wiley   +1 more source

Data_Sheet_1_Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.docx [PDF]

, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Andrea Deinzer (6873245), Alexander Steinkasserer (6541064), Lena Stich (6541058), Christine Kuhnt (6873248), Ilka Knippertz (641020), Elisabeth Zinser (6541067), Julia Michalski (6873242), Andreas B. Wild (6873239), Ronald Naumann (164582)   +8 more
core   +1 more source

Expression of chicken DEC205 reflects the unique structure and function of the avian immune system.

PLoS ONE, 2013
The generation of appropriate adaptive immune responses relies critically on dendritic cells, about which relatively little is known in chickens, a vital livestock species, in comparison with man and mouse. We cloned and sequenced chicken DEC205 cDNA and
Karen Staines, John R Young, Colin Butter   +2 more
doaj   +1 more source

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin‐1 in B Cells

Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
Ataxin‐1 has been recently implicated in B cell regulation in the context of multiple sclerosis pathology. In this study, we used a multiomics pipeline to profile the B cell transcriptome, epigenome, and proteome in response to encephalitogenic challenges.
Jonathan J. Carver, Rachael R. Denbrock, Kristy M. Lau, Tonya N. Zeczycki, Changhong Yin, Weihua Huang, Alessandro Didonna   +6 more
wiley   +1 more source

The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells [PDF]

, 2017
Human cytomegalovirus (HCMV) is the prototypic beta-herpesvirus and widespread throughout the human population. While infection is asymptomatic in healthy individuals, it can lead to high morbidity and mortality in immunocompromised persons. Importantly,
Christiane S. Heilingloh, Mühl-Zürbes, Petra, Petra Mühl-Zürbes, Myriam Scherer, Mirko Kummer, Kummer, Mirko, Grosche, Linda, Thomas Stamminger, Stamminger, Thomas, Steinkasserer, Alexander, Lisa Kamm, Heilingloh, Christiane S., Latzko, Melanie, Kamm, Lisa, Scherer, Myriam, Alexander Steinkasserer, Melanie Latzko, Linda Grosche   +17 more
core   +2 more sources

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 3, June 2026.
Immunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Katherine Yaacoub
wiley   +1 more source

CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions [PDF]

, 2003
Multiple sclerosis (MS) has a wide spectrum of clinical courses, characterized by multifocal central nervous system (CNS) damage, postulated to be mediated by CNS antigen-specific T cells.
Plumb, J., Duddy, M., McQuaid, Stephen, Mirakhur, M., Armstrong, M. A.   +4 more
core