Results 81 to 90 of about 448,583 (189)

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, Volume 40, Issue 10, Page 5951-5972, October 2026.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

The CD83 Molecule – An Important Immune Checkpoint

, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Royzman, Dmytro, Lechmann, Matthias, König, Christina, Muller, Yves A., Knippertz, Ilka, Wild, Andreas B., Grosche, Linda, Zinser, Elisabeth, Steinkasserer, Alexander, Sticht, Heinrich   +9 more
core   +1 more source

Low-frequency ultrasound-induced VEGF suppression and synergy with dendritic cell-mediated anti-tumor immunity in murine prostate cancer cells in vitro

Scientific Reports, 2017
High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been ...
Wei Zhang, Wen-De Shou, Yan-Jun Xu, Wen-Kun Bai, Bing Hu   +4 more
doaj   +1 more source

Analysis of Nucleocytoplasmic Trafficking of the HuR Ligand APRIL and Its Influence on CD83 Expression

, 2007
Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system and are able to sensitize even naive T cells. Mature DC are characterized by expression of CD83, a surface molecule that is proposed to be involved in efficient T cell
Heukeshoven, Jochen, Chemnitz, Jan, Joachim Hauber, Barbara Fries, Kehlenbach, Ralph H., Hauber, Ilona, Ilona Hauber, Fries, Barbara, Cordula Grüttner, Jan Chemnitz, Stocking, Carol, Carol Stocking, Gruettner, Cordula, Jochen Heukeshoven, Ralph H. Kehlenbach, Hall, Joachim   +15 more
core   +1 more source

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4

Cell Reports
Summary: While professional antigen-presenting cells drive adaptive immunity, atypical cell types can fulfill this role in the bone marrow. Megakaryocytes (MKs) are canonically recognized for platelet production, but recent studies indicate functional ...
Virginia Camacho, Karen G. Wang, Pavel Hanč, Estelle Carminita, Isabelle C. Becker, Dong H. Lee, Mahmoud A. Bassal, Marcelo Falchetti, Jaxaira Maggi, Maria Barrachina, Ulrich von Andrian, Montserrat Carrascal, Deepa Gautam, Chen Weng, Vijay G. Sankaran, Joseph E. Italiano, Kellie R. Machlus   +16 more
doaj   +1 more source

In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells

Journal of Translational Medicine, 2008
Background Human hepatocellular carcinoma (HCC) cells express WT1 and/or carcinoembryonic antigen (CEA) as potential targets for the induction of antitumor immunity. In this study, generation of cytotoxic T lymphocytes (CTL) and regulatory T cells (Treg)
Sagawa Yukiko, Komita Hideo, Nagasaki Eijiro, Takahara Akitaka, Namiki Yoshihisa, Mitsunaga Makoto, Hara Eiichi, Homma Sadamu, Koido Shigeo, Ohkusa Toshifumi, Fujise Kiyotaka, Gong Jianlin, Tajiri Hisao   +12 more
doaj   +1 more source

Das CD83-Molekül ist ein neues Zielgen des Aryl-Hydrocarbon-Rezeptors in humanen dendritischen Zellen [PDF]

, 2020
Project 1: The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is a promising therapeutic target for the regulation of dendritic cell (DC)-mediated antigen-specific tolerance in autoimmune diseases.
Michalski, Julia
core  

Platelet concentrates modulate myeloid dendritic cell immune responses

Platelets, 2018
Platelet transfusion has been reported to modulate the recipients’ immune system. To date, the precise mechanism(s) driving poor patient outcomes (e.g., increased rate of mortality, morbidity, infectious complications and prolonged hospital stays ...
Katrina K. Ki, Helen M. Faddy, Robert L. Flower, Melinda M. Dean   +3 more
doaj   +1 more source

Screening and Identification of a Chicken Dendritic Cell Binding Peptide by Using a Phage Display Library

Frontiers in Immunology, 2019
Dendritic cells (DCs), as antigen-presenting cells, can initiate adaptive immune responses efficiently. Although the DC-targeting strategy has attracted more attention, relevant studies on chicken are rare.
Sunting Ma, Sunting Ma, Sunting Ma, Xinyuan Qiao, Xinyuan Qiao, Yigang Xu, Yigang Xu, Li Wang, Han Zhou, Yanping Jiang, Wen Cui, Xuewei Huang, Xiaona Wang, Lijie Tang, Lijie Tang, Yijing Li, Yijing Li   +16 more
doaj   +1 more source

CD83 Modulates B Cell Activation and Germinal Center Responses

, 2016
CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear.
Urbat, Anne, Steinkasserer, Alexander, Christine Seitz, Joachim Gläsner, Krzyzak, Lena, Hiergeist, Andreas, Winkler, Thomas H., Seitz, Christine, Nitschke, Lars, Lena Krzyzak, Hutzler, Stefan, Thomas H. Winkler, Stefan Hutzler, Christian Ostalecki, Gläsner, Joachim, Gessner, André, André Gessner, Lars Nitschke, Alexander Steinkasserer, Andreas Hiergeist, Ostalecki, Christian, Anne Urbat   +21 more
core   +1 more source