Results 281 to 290 of about 124,972 (317)

CD28–CD80/CD86 Interactions in testicular immunoregulation

Journal of Reproductive Immunology, 1996
The expression of two accessory molecules on antigen-presenting cells (APC), the CD80/ B7-1 and CD86/B7-2 antigens, was studied in the testis of normal and non-obese diabetic (NOD) mice. In addition, the effect of CD28 stimulation on suppression of lymphocytes by testicular products was investigated.
S, Sainio-Pöllänen, T, Saari, O, Simell, P, Pöllänen   +3 more
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CD86 gene variants and susceptibility to pancreatic cancer

Journal of Cancer Research and Clinical Oncology, 2012
Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity. It has been reported that polymorphisms in CD86 gene can be involved in the development of various cancers. Here, we investigated the association of two CD86 polymorphisms, +1057G/
Honggang, Xiang, Wei, Zhao, Yanping, Sun, Winnie, Qian, Junjie, Xing, Yujia, Zhou, Jun, Yao, Jian, Xu, Yi, Wang, Houshan, Yao, Zhiqian, Hu   +10 more
openaire   +2 more sources

Regulation of self-tolerance by CD80/CD86 interactions

Current Opinion in Immunology, 1997
Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from ...
P, Lu, Y L, Wang, P S, Linsley
openaire   +2 more sources

CD28/CTLA-4 and CD80/CD86 families

Immunologic Research, 1999
T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of which can prevent anergy and cell death. The CD28 receptor is a member of a complex family of polypeptides that includes at least two receptors and two ligands ...
J M, Slavik, J E, Hutchcroft, B E, Bierer   +2 more
openaire   +2 more sources

Analysis of CD80 and CD86 Expression on Peripheral Blood B Lymphocytes Reveals Increased Expression of CD86 in Lupus Patients

Clinical Immunology and Immunopathology, 1997
We screened peripheral blood mononuclear cells from 13 SLE patients, all having quiescent disease at the time of analysis, 12 allergy patients, and 21 normal subjects for the expression of CD80 (B7-1) and CD86 (B7-2, B70) on small (resting) and large (activated) subsets of CD19+ B cells.
D, Folzenlogen, M F, Hofer, D Y, Leung, J H, Freed, M K, Newell   +4 more
openaire   +2 more sources

Increases of CD80 and CD86 Expression on Peripheral Blood Cells and their Gene Polymorphisms in Autoimmune Thyroid Disease

Immunological Investigations, 2019
The prognosis of autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are difficult to predict. Both CD80 and CD86 costimulatory signals promote T cell activation in cooperation with T cell receptor signal.
A. Watanabe, N. Inoue, Mikio Watanabe, Mayu Yamamoto, Haruka Ozaki, Y. Hidaka, Y. Iwatani   +6 more
semanticscholar   +1 more source

The role of B7-2 (CD86) in tumour immunity

Expert Opinion on Investigational Drugs, 1997
Tumour cells engineered to express co-stimulatory molecules on their surface provide researchers with powerful new tools to manipulate antitumour responses. It has been demonstrated that B7-1+ and B7-2+ tumour cells can elicit effective responses against their wild-type counterparts.
G, Yang, K E, Hellström, L, Chen
openaire   +2 more sources

What's the difference between CD80 and CD86?

Trends in Immunology, 2003
CD28 and CD152 have crucial yet opposing functions in T-cell stimulation, in which CD28 promotes but CD152 inhibits T-cell responses. Intriguingly, they share two ligands, CD80 and CD86, but at present there is no clear model for understanding whether a ligand will promote or inhibit responses. Current perceptions are based around the concept that CD86
David M, Sansom, Claire N, Manzotti, Yong, Zheng   +2 more
openaire   +2 more sources

CD86 + 1057G/A Polymorphism and Susceptibility to Osteosarcoma

DNA and Cell Biology, 2011
CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity. CD86 + 1057G/A polymorphism (rs1129055) is associated with various diseases. The objective of this study was to investigate the association between CD86  + 1057G/A polymorphism and ...
Wen, Wang, Haihan, Song, Jie, Liu, Bao, Song, Xuecheng, Cao   +4 more
openaire   +2 more sources

Dynamics of CD86 Expression on Allergic Inflammation - New Insights

Recent Patents on Inflammation & Allergy Drug Discovery, 2009
CD86 is a well-known costimulatory molecule in its interaction with CD28 and/or CTLA present on T cells, and is essential for full activation of naïve T-cell and subsequent differentiation. Usually the B7 molecules are expressed mainly on APCs and B cells and in specific conditions on other activated cells. These costimulatory molecules are involved in
Celso, Pereira, Beatriz, Tavares, Graça, Loureiro, Artur, Paiva, Ana, Henriques, Margarida, Abrantes, Daniel, Machado, Filomena, Botelho, Manuel F, Baganha   +8 more
openaire   +2 more sources