Results 291 to 300 of about 124,972 (317)

Costimulatory molecules CD80 and CD86 in human crescentic glomerulonephritis

American Journal of Kidney Diseases, 2003
CD80 and CD86, cell-surface molecules found only on antigen-presenting cells (APCs), are required for activation of CD4-postitve (CD4+) T cells by interaction with CD28/cytotoxic T-lymphocyte-associated antigen 4 on T cells. The roles of these molecules in human glomerulonephritis (GN) presently are unknown.Twelve cases of crescentic GN, thought to be ...
Qiong, Wu, Kiichiro, Jinde, Masayuki, Endoh, Hideto, Sakai   +3 more
openaire   +2 more sources

Interactions of CD80 and CD86 with CD28 and CTLA4

The Journal of Immunology, 1996
Abstract CD80 and CD86 are cell surface glycoproteins expressed on a variety of professional APCs. They have attracted much attention due to their function as potent costimulators of T lymphocyte function through their interaction with CD28 and possibly CTLA4. Because inhibitors of this interaction may have therapeutic relevance in human
J H, Ellis, M N, Burden, D V, Vinogradov, C, Linge, J S, Crowe   +4 more
openaire   +2 more sources

Immunophenotypic Analysis Using CD80 and CD86 Staining Improves the Diagnosis of Waldenstrom's Macroglobulinemia by Evidencing a CD80+/CD86- Profile.

Blood, 2009
Abstract Abstract 4389 The immunophenotypic characterization is an essential tool in the diagnosis of hematological malignancies but the immunophenotypic profile of Waldenstrom's macroglobulinemia (WM) B cells remains not clearly defined. In order to improve the diagnosis of WM by an immunophenotypic peripheral blood test,
Andrea Toma, Stephanie Poulain, Aurore Grelier, Magali Le Garff-Tavernier, Frederic Davi, Martine Brissard, Patrick Bonnemye, Stephanie Gueguen, Lucille Musset, Nabih Azar, Pierre Morel, Xavier Leleu, Veronique Leblond, Helene Merle-Beral   +13 more
openaire   +1 more source

Identification of an Alternatively Spliced Variant of Human CD86 mRNA

Biochemical and Biophysical Research Communications, 2001
CD86 is a costimulatory molecule constitutively expressed by human antigen presenting cells which interacts with CD28 and CTLA-4 expressed by T cells. We have recently reported the identification of an alternatively spliced CD86 mRNA variant (CD86deltaTM) characterized by the deletion of exon 6 which encodes for the transmembrane domain. We report here
G, Magistrelli, G, Caron, J F, Gauchat, P, Jeannin, J Y, Bonnefoy, Y, Delneste   +5 more
openaire   +2 more sources

Anti-CD86 (B7.2) Treatment Abolishes Allergic Airway Hyperresponsiveness in Mice

American Journal of Respiratory and Critical Care Medicine, 1999
Allergic sensitization in asthma develops as a consequence of complex interactions between T cells and antigen-presenting cells. We have developed several in vivo models to study allergen-specific T cell and B cell function and their relevance to allergic airway hyperresponsiveness (AHR), focusing on the role of the costimulatory molecules CD80 and ...
A, Haczku, K, Takeda, I, Redai, E, Hamelmann, G, Cieslewicz, A, Joetham, J, Loader, J J, Lee, C, Irvin, E W, Gelfand   +9 more
openaire   +2 more sources

Downregulation of CD86 in HCMV‐infected THP‐1 cells

Microbiology and Immunology
AbstractMonocytes and macrophages are at the frontline of defense against pathogens. Human cytomegalovirus (HCMV) uses myeloid cells as vehicles to facilitate viral dissemination. HCMV infection in monocytes and macrophages leads to the downregulation of several cell surface markers via an undefined mechanism.
Tetsuo Koshizuka, Yuta Sasaki, Hiroki Kondo, Juri Koizumi, Keita Takahashi   +4 more
openaire   +2 more sources

Induction of oral tolerization in CD86 deficient mice: A role for CD86 and B cells in the up-regulation of TGF-β

Journal of Autoimmunity, 2006
Feeding myelin oligodendrocyte glycoprotein (MOG) followed by immunization results in induction of oral tolerance evidenced by the amelioration of experimental autoimmune encephalomyelitis (EAE). Oral tolerization is characterized by the suppression of Th1 responses and up-regulation of Th2 responses and TGF-beta.
Patricia A, Gonnella, Youhai H, Chen, Hanspeter, Waldner, Howard L, Weiner   +3 more
openaire   +2 more sources

Molecular cloning, expression and functional characterization of miniature swine CD86

Molecular Immunology, 2006
CD86 is one of the key molecules involved in the co-stimulation of T cells. The complete cDNA encoding CD86 molecule of miniature swine was cloned and analyzed. A comparison of two CD86 amino acid sequences of miniature swine and domestic swine showed only three amino acid differences suggesting that it is unlikely to affect the major structural ...
Inho, Choi, Bumrae, Cho, Sung Dae, Kim, Dongkyoo, Park, Jae Young, Kim, Chung-Gyu, Park, Doo Hyun, Chung, Woo Suk, Hwang, Jung Sang, Lee, Curie, Ahn   +9 more
openaire   +2 more sources

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity

Nature Immunology, 2020
Shinya Tanaka, W. Ise, Takeshi Inoue, Ayako Ito, C. Ono, Y. Shima, S. Sakakibara, M. Nakayama, K. Fujii, I. Miura, J. Sharif, H. Koseki, P. Koni, Indu Raman, Quanzhen Li, M. Kubo, Katsunori Fujiki, Ryuichiro Nakato, K. Shirahige, Hiromitsu Araki, F. Miura, Takashi Ito, Eiryo Kawakami, Y. Baba, T. Kurosaki   +24 more
semanticscholar   +1 more source

CD86

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source