Results 51 to 60 of about 378,605 (167)

Diversity in CD8+ T cell differentiation [PDF]

Current Opinion in Immunology, 2009
CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on how CD8(+) T cell responses are ...
Parish, Ian, Kaech, Susan
openaire   +3 more sources

Enhanced neointima formation following arterial injury in immune deficient Rag-1-/- mice is attenuated by adoptive transfer of CD8 T cells. [PDF]

PLoS ONE, 2011
T cells modulate neointima formation after arterial injury but the specific T cell population that is activated in response to arterial injury remains unknown.
Paul C Dimayuga, Kuang-Yuh Chyu, Jonathan Kirzner, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Prediman K Shah, Bojan Cercek   +7 more
doaj   +1 more source

Sifting through CD8 + T Cell Memory [PDF]

Immunity, 2016
In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8+ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8+ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue ...
Matthew D, Martin, Vladimir P, Badovinac
openaire   +2 more sources

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. [PDF]

PLoS Pathogens, 2016
The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is ...
Korey R Demers, George Makedonas, Marcus Buggert, Michael A Eller, Sarah J Ratcliffe, Nilu Goonetilleke, Chris K Li, Leigh Anne Eller, Kathleen Rono, Lucas Maganga, Sorachai Nitayaphan, Hannah Kibuuka, Jean-Pierre Routy, Mark K Slifka, Barton F Haynes, Andrew J McMichael, Nicole F Bernard, Merlin L Robb, Michael R Betts   +18 more
doaj   +1 more source

Memory CD8 T cell transcriptional plasticity [PDF]

F1000Prime Reports, 2015
Memory CD8 T cells generated after acute viral infections or live vaccines can persist for extended periods, in some instances for life, and play an important role in protective immunity. This long-lived immunity is achieved in part through cytokine-mediated homeostatic proliferation of memory T cells while maintaining the acquired capacity for rapid ...
Youngblood, Ben, Hale, J. Scott, Ahmed, Rafi   +2 more
openaire   +2 more sources

CD8 Controls T Cell Cross-Reactivity [PDF]

The Journal of Immunology, 2010
Abstract Estimates of human αβ TCR diversity suggest that there are <108 different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered.
Wooldridge, Linda, Laugel, Bruno, Ekeruche, Julia, Clement, Mathew, van den Berg, Hugo A, Price, David A, Sewell, Andrew K   +6 more
openaire   +3 more sources

CD8+ T cell-based cancer immunotherapy

Journal of Translational Medicine
AbstractThe immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological threats. Various immunotherapies based on CD8+ T cells have emerged in recent decades, showing their promising results in treating intractable diseases.
Yanxia Chen, Dingning Yu, Hui Qian, Yinghong Shi, Zhimin Tao   +4 more
openaire   +3 more sources

BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation

Molecular Medicine
Background It is well-established that CD8+ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes.
Chenghao Li, Zongtao Liu, Zihao Wang, Wai Yen Yim, Yajun Huang, Yuqi Chen   +5 more
doaj   +1 more source

FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors

Journal of Biomedical Science
Background Previous research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendritic cells (DCs) from bone marrow progenitors, with a limited understanding of how these cells affect CD8 T cell function.
Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T. C. Wu, Chien-Fu Hung   +8 more
doaj   +1 more source

Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection

Immunity, Inflammation and Disease
Backgrounds and Aims CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV‐specific CD8+T cells.
Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang   +9 more
doaj   +1 more source