Results 1 to 10 of about 42,229 (197)

Precise mapping of the CD95 pre-ligand assembly domain. [PDF]

PLoS ONE, 2012
Pre-association of CD95 at the plasma membrane is mandatory for efficient death receptor signaling. This homotrimerization occurs through self-association of an extracellular domain called the pre-ligand assembly domain (PLAD).
Valérie Edmond, Benoist Ghali, Aubin Penna, Jean-Luc Taupin, Sophie Daburon, Jean-François Moreau, Patrick Legembre   +6 more
doaj   +20 more sources

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation. [PDF]

PLoS ONE, 2011
Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of TRAIL-receptor (R) is essential for sensitivity and resistance towards TRAIL-mediated apoptosis. In this
Olga M Shatnyeva, Andriy V Kubarenko, Claudia E M Weber, Alexander Pappa, Reinhard Schwartz-Albiez, Alexander N R Weber, Peter H Krammer, Inna N Lavrik   +7 more
doaj   +4 more sources

ZBTB7A regulates CD95-mediated cell growth in colorectal cancer cell lines. [PDF]

PLoS ONE
Zinc Finger and BTB Domain-containing7A (ZBTB7A) is a member of the transcription factor family that regulates the expression of numerous genes involved in cell proliferation and differentiation.
Yanhong Bie, Meiying Bie, Wang Liu, Shufang Tao, Hongyu Xing, Linlin Kuang, Yi Song   +6 more
doaj   +2 more sources

Dengue Viral Infection Induces Alteration of CD95 Expression in B Cell Subsets with Potential Involvement of Dengue Viral Non-Structural Protein 1 [PDF]

Viruses
Little is known about the regulation of B cell subpopulations in association with programmed cell death during dengue virus (DENV) infection. Therefore, blood samples from dengue-infected patients and healthy donors were obtained for B cell subset ...
Siyu Wang, Premrutai Thitilertdecha, Ladawan Khowawisetsut, Theeraporn Maneesawat, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kovit Pattanapanyasat, Nattawat Onlamoon   +7 more
doaj   +2 more sources

Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury

Gut Microbes, 2022
The intestinal flora plays an important role in the development of many human and animal diseases. Microbiome association studies revealed the potential regulatory function of intestinal bacteria in many liver diseases, such as autoimmune hepatitis ...
Hesuiyuan Wang, Qing Wang, Chengmao Yang, Mingming Guo, Xiaoyue Cui, Zhe Jing, Yujie Liu, Wanjin Qiao, Hang Qi, Hongyang Zhang, Xu Zhang, Na Zhao, Mengjuan Zhang, Min Chen, Song Zhang, Haijin Xu, Liqing Zhao, Mingqiang Qiao, Zhenzhou Wu   +18 more
doaj   +1 more source

CD95 gene deletion may reduce clonogenic growth and invasiveness of human glioblastoma cells in a CD95 ligand-independent manner

Cell Death Discovery, 2022
CD95 (Fas/APO-1) is a multifunctional cell surface receptor with antithetic roles. First described to mediate cell death, interactions of CD95 with its natural ligand, CD95L, have also been described to induce tumor-promoting signaling leading to ...
Clara Quijano-Rubio, Manuela Silginer, Michael Weller   +2 more
doaj   +1 more source

Involvement of CD95 and ligand in CD4+ T-cell and CD8+ T-cell depletion and hepatic cytolysis in patients with chronic viral hepatitis B

African Journal of Laboratory Medicine, 2021
Background: Chronic viral hepatitis B (HBV) is characterised by progressive hepatocyte destruction and T-cell depletion. The mechanisms of the CD95-CD95 ligand (CD95L) signalling pathway during this chronic disease and the cirrhotic process remains ...
Franklin S. Azebaze Agueguia, Paul Talla, Marie C. Okomo Assoumou, Graeme B. Jacobs, Cedric H. Mbakam, Elise Guiedem, Martha Tongo Mesembe, Emilia Lyonga, George Mondinde Ikomey   +8 more
doaj   +1 more source

Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19

iScience, 2023
Summary: Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that the direct interaction of AEC with macrophages mediated by CD95/CD95L or indirect interaction mediated by IL-6 ...
Thais F.C. Fraga-Silva, Ualter G. Cipriano, Marcilio J. Fumagalli, Giseli F. Correa, Carlos A. Fuzo, Douglas dos-Santos, Fabiola L.A.C. Mestriner, Christiane Becari, Andrea Teixeira-Carvalho, Jordana Coelho-dos-Reis, Mayra G. Menegueti, Luiz T.M. Figueiredo, Larissa D. Cunha, Olindo A. Martins-Filho, Marcelo Dias-Baruffi, Maria Auxiliadora-Martins, Rita C. Tostes, Vania L.D. Bonato   +17 more
doaj   +1 more source

Immunoexpression of CD95 in chronic gastritis and gastric mucosa-associated lymphomas [PDF]

Brazilian Journal of Medical and Biological Research, 2004
CD95 (Fas/APO-1)-mediated apoptosis plays an important role in immunological regulation and is related to the pathogenesis of autoimmune diseases.
Vassallo J., Godoy Jr. C.E., Godoy C.E., Chagas C.A., Metze K., Trevisan M.A.S.   +5 more
doaj   +3 more sources

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

iScience, 2021
Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth.
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre   +5 more
doaj   +1 more source