Results 11 to 20 of about 42,229 (197)
Death Induced by CD95 or CD95 Ligand Elimination
Cell Reports, 2014 CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL ...
Abbas Hadji +13 more
doaj +3 more sources
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
iScience, 2021 Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth.
Abdul S. Qadir +18 more
doaj +1 more source
CD95-tyrosine Nitration Inhibits Hyperosmotic and CD95 Ligand-induced CD95 Activation in Rat Hepatocytes [PDF]
Journal of Biological Chemistry, 2004 Epidermal growth factor receptor-dependent CD95-tyrosine phosphorylation was recently identified as an early step in apoptosis induction via the CD95 system (Reinehr, R., Schliess, F., and Häussinger, D. (2003) FASEB J. 17, 731-733). The effect of peroxynitrite (ONOO(-)) on modulation of the hyperosmotic and CD95 ligand (CD95L)-induced CD95 activation ...
Roland, Reinehr +3 more
openaire +2 more sources
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]
, 1994 Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M +7 more
core +2 more sources
The role of CD95 and CD95 ligand in cancer [PDF]
Cell Death & Differentiation, 2015 CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. In addition, these molecules are important in the immune elimination of virus-infected cells and cancer cells. CD95L was, therefore, considered to be useful for cancer therapy.
M E Peter +6 more
openaire +2 more sources
Инфекция и иммунитет, 2017 Infectious mononucleosis is a widespread disease caused by certain members of Herpesviridae family. Acute infectious mononucleosis develops predominantly in children and is accompanied by an increase of the number of circulating naive CD4+ and naive CD8+
E. N. Filatova +4 more
doaj +1 more source
In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]
, 2019 Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi +32 more
core +2 more sources
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease
Сахарный диабет, 2009 Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods.
Elena Vladimirovna Pekareva +6 more
doaj +1 more source
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways
Cell Death and Disease, 2022 CD95 is a death receptor that can promote oncogenesis through molecular mechanisms that are not fully elucidated. Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the signal peptide ...
Shoji F. Kenji +12 more
doaj +1 more source
Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
core +1 more source